Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications.
Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications.
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DOI：
10.3390/ijms22052360
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发表时间：
2021-02-26
影响因子：
5.6
通讯作者：
Mao X
中科院分区：
文献类型：
--
作者：
Wang L;Mao X
已经在视网膜中鉴定出淀粉样蛋白-β（Aβ）积聚，用于神经变性相关疾病，如阿尔茨海默病（AD）、青光眼和年龄相关性黄斑变性（AMD）。视网膜Aβ水平升高与进行性视网膜神经变性、脑Aβ蓄积升高以及疾病严重程度增加伴认知和视力下降相关。已证明视网膜Aβ蓄积及其病理效应发生在不可逆神经变性之前，这突出了其在早期疾病检测和干预中的潜力。使用视网膜作为大脑的模型，最近的研究集中在表征视网膜Aβ，以确定其对基于人群的AD筛查的适用性，这需要进一步了解Aβ在这些疾病之间的表现。虽然目前直接靶向Aβ蓄积的治疗效果有限，但对Aβ相关病理通路的持续探索可能会产生保护认知和视力的新治疗靶点。在这里，我们提供了一个审查的作用，视网膜Aβ表现在这些不同的神经变性相关疾病。我们还讨论了视网膜Aβ在AD筛查中的最新应用以及Aβ相关治疗方法的当前临床试验结果。最后，我们探索潜在的未来治疗目标的基础上重叠的病理生理机制，在AD，青光眼，AMD。
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-associated disorders like Alzheimer’s disease (AD), glaucoma, and age-related macular degeneration (AMD). Elevated retinal Aβ levels were associated with progressive retinal neurodegeneration, elevated cerebral Aβ accumulation, and increased disease severity with a decline in cognition and vision. Retinal Aβ accumulation and its pathological effects were demonstrated to occur prior to irreversible neurodegeneration, which highlights its potential in early disease detection and intervention. Using the retina as a model of the brain, recent studies have focused on characterizing retinal Aβ to determine its applicability for population-based screening of AD, which warrants a further understanding of how Aβ manifests between these disorders. While current treatments directly targeting Aβ accumulations have had limited results, continued exploration of Aβ-associated pathological pathways may yield new therapeutic targets for preserving cognition and vision. Here, we provide a review on the role of retinal Aβ manifestations in these distinct neurodegeneration-associated disorders. We also discuss the recent applications of retinal Aβ for AD screening and current clinical trial outcomes for Aβ-associated treatment approaches. Lastly, we explore potential future therapeutic targets based on overlapping mechanisms of pathophysiology in AD, glaucoma, and AMD.
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影响因子：
5
作者：
Dao, Pascal;Ye, Fefei;Chen, Huixiong
通讯作者：
Chen, Huixiong
DOI：
10.1523/jneurosci.6393-09.2010
发表时间：
2010-03-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Davis AA;Fritz JJ;Wess J;Lah JJ;Levey AI
通讯作者：
Levey AI
影响因子：
--
作者：
Bamburg, James R.;Bloom, George S.
通讯作者：
Bloom, George S.
影响因子：
3.7
作者：
Cifuentes-Canorea P;Ruiz-Medrano J;Gutierrez-Bonet R;Peña-Garcia P;Saenz-Frances F;Garcia-Feijoo J;Martinez-de-la-Casa JM
通讯作者：
Martinez-de-la-Casa JM
影响因子：
1.8
作者：
Cano, Marisol;Thimmalappula, Rajesh;Fujihara, Masashi;Nagai, Norihiro;Sporn, Michael;Wang, Ai Ling;Neufeld, Arthur H.;Biswal, Shyam;Handa, James T.
通讯作者：
Handa, James T.