Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy
Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy
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原发性先天性扩张型心肌病产后临床病程的预测
DOI：
10.1111/ped.14029
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发表时间：
2019
影响因子：
1.4
通讯作者：
Kato Taichi
中科院分区：
文献类型：
--
作者：
Yamamoto Hidenori;Fukasawa Yoshie;Ohashi Naoki;Yokoyama Takehiko;Suzuki Kazutaka;Ota Takaya;Yasuda Kazushi;Omoya Kentaro;Takahashi Yoshiyuki;Kato Taichi
BackgroundThe本研究的目的是探讨使用胎儿和围产期的数据与原发性先天性扩张型心肌病（PCDCM）的患者的产后预后的预测，并估计这种疾病的发病率。MethodsWe检查胎儿或围产期的数据和产后的临床过程中的8例PCDCM患者的多中心回顾性研究之间的相关性。发病率计算在人口为基础的study.ResultsAll患者发生心力衰竭的中位数为8天（范围，0-43天），和6例患者死亡或需要体外人工心脏治疗的中位数为67天（范围，0-92天）。胎儿超声心动图的心胸面积比、Apgar评分和出生体重标准差与心力衰竭发作日期显著相关。然而，没有数据与生存相关。PCDCM的累积发病率计算为1.21/100000总出生结论原发性先天性扩张型心肌病预后不良，但胎儿超声心动图的心胸面积比、出生时体重和Apgar评分与心力衰竭发作时间相关，因此，这些指标可能对产前和产后管理有用。
BackgroundThe aim of this study was to investigate the prediction of postnatal prognosis using fetal and perinatal data in patients with primary congenital dilated cardiomyopathy (PCDCM), and to estimate the incidence of this disease.MethodsWe examined correlations between fetal or perinatal data and postnatal clinical course in a multicenter retrospective study of eight patients with PCDCM. Incidence was calculated in a population‐based study.ResultsAll patients developed heart failure at a median of 8 days (range, 0–43 days), and six patients died or required extracorporeal artificial heart therapy at a median of 67 days (range, 0–92 days). The cardiothoracic area ratio from fetal echocardiography, the Apgar score, and the standard deviation of birth weight correlated significantly with the date at onset of heart failure. However, no data correlated with survival. Cumulative incidence of PCDCM was calculated as 1.21 per 100 000 total births (95% confidence interval, 0.37 to 2.06).ConclusionsPrimary congenital dilated cardiomyopathy has a poor prognosis, but cardiothoracic area ratio from fetal echocardiography, body weight at birth, and Apgar score correlate with the timing of the onset of heart failure, and these indicators might therefore be useful for peri‐ and postnatal management.
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