Gastrointestinal system.
Gastrointestinal system.
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DOI：
10.1002/wsbm.19
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发表时间：
2010-01
影响因子：
7.9
通讯作者：
Pullan, Andrew J.
中科院分区：
文献类型：
--
作者：
Cheng, Leo K.;O'Grady, Gregory;Du, Peng;Egbuji, John U.;Windsor, John A.;Pullan, Andrew J.
胃肠道的功能包括消化、吸收、排泄和保护。在这篇综述中，我们专注于胃和小肠的电活动，这是这些器官运动的基础，迄今为止，最详细的系统描述和计算模型都是基于此。大部分的讨论也适用于胃肠道的其余部分。这篇综述涵盖了四个主要的空间尺度：细胞，组织，器官和躯干，并讨论了调查方法和与每个相关的挑战。我们开始描述的起源，在Cajal间质细胞的电活动，其蔓延到平滑肌细胞。然后描述电活动通过胃和小肠的传播，随后是可以在身体表面上记录的所产生的电和磁活动。许多常见的和高度症状性的胃肠道疾病涉及异常的电和/或运动活动，这通常被称为功能性疾病。在本综述的最后一节中，我们讨论了用于表征和诊断电活动异常的方法，以及这些方法如何应用于临床。对胃肠道系统电生理学和动力学的理解仍然是一个具有挑战性的领域，该综述讨论了基于生物医学的数学模型如何通过整合其他独立的概念来帮助弥合我们现有知识中的差距。
The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and computational models have been based to date. Much of this discussion is also applicable to the rest of the GI tract. This review covers four major spatial scales: cell, tissue, organ, and torso, and discusses the methods of investigation and the challenges associated with each. We begin by describing the origin of the electrical activity in the interstitial cells of Cajal, and its spread to smooth muscle cells. The spread of electrical activity through the stomach and small intestine is then described, followed by the resultant electrical and magnetic activity that may be recorded on the body surface. A number of common and highly symptomatic GI conditions involve abnormal electrical and/or motor activity, which are often termed functional disorders. In the last section of this review we address approaches being used to characterize and diagnose abnormalities in the electrical activity and how these might be applied in the clinical setting. The understanding of electrophysiology and motility of the GI system remains a challenging field, and the review discusses how biophysically based mathematical models can help to bridge gaps in our current knowledge, through integration of otherwise separate concepts.
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影响因子：
3.9
作者：
Austin, Travis M.;Li, Liren;Cheng, Leo K.
通讯作者：
Cheng, Leo K.
影响因子：
3.4
作者：
BARR, RC;PLONSEY, R
通讯作者：
PLONSEY, R
影响因子：
--
作者：
BAUER, AJ;PUBLICOVER, NG;SANDERS, KM
通讯作者：
SANDERS, KM
DOI：
10.1152/ajpgi.1997.272.5.g1159
发表时间：
1997-05-01
影响因子：
4.5
作者：
Bradshaw, LA;Allos, SH;Richards, WO
通讯作者：
Richards, WO
影响因子：
4.6
作者：
Bradshaw, LA;Ladipo, JK;Richards, WO
通讯作者：
Richards, WO