Chronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China.
Chronic maternal hepatitis B virus infection and pregnancy outcome- a single center study in Kunming, China.
复制标题
孕产妇慢性乙型肝炎病毒感染与妊娠结局——中国昆明的单中心研究
DOI：
10.1186/s12879-021-05946-7
复制
发表时间：
2021-03-10
影响因子：
3.7
通讯作者：
Ma R
中科院分区：
文献类型：
--
作者：
Sun Q;Lao TT;Du M;Xie M;Sun Y;Bai B;Ma J;Zhu T;Yu S;Ma R
背景中国人群中慢性乙型肝炎病毒（HBV）感染率较高，其对妊娠结局的影响仍存在争议。我们在中国西南多民族城市昆明进行了一项单中心回顾性队列研究来研究这一问题。方法以我院2005-2017年收治的≥28周单胎妊娠患者为研究队列。在常规产前筛查中检测乙型肝炎表面抗原（HBsAg）血清阳性和非HBsAg血清阳性的母亲之间比较了母亲的特征和妊娠结局。结果该队列49479例孕妇中，1624例（3.3%）HBsAg血清阳性孕妇未生育（RR 0.963, 95% CI 0.935-0.992）和受过高等教育（RR 0.829, 95% CI 0.784-0.827）的发生率较低。两组患者的病史、妊娠并发症、分娩或围产期结局均无显著差异，但HBV携带者的引产发生率（RR 0.827, 95% CI 0.714-0.958）和小胎龄儿（SGA）发生率（RR 0.854, 95% CI 0.734-0.994）显著低于对照组。在回归分析中，母体HBV携带与自然分娩（aRR 1.231, 95% CI 1.044-1.451）和SGA婴儿减少（aRR 0.842, 95% CI 0.712-0.997）独立相关。结论3.3%的孕产妇乙肝病毒感染率处于较低水平。与自然分娩和减少SGA婴儿的关联可能有助于通过提高出生时感染的后代的存活率来促进感染的持续存在，从而解释了中国人群中高患病率的原因。
BackgroundChinese population has a high prevalence of chronic hepatitis B virus (HBV) infection, the impact of which on pregnancy outcome remains controversial. A single-center retrospective cohort study was performed in Kunming, a multi-ethnic city in south-western China to examine this issue.MethodsThe singleton pregnancies delivering at ≥28 weeks gestation under our care in 2005–2017 constituted the study cohort. Maternal characteristics and pregnancy outcome were compared between mothers with and without seropositivity for hepatitis B surface antigen (HBsAg) determined at routine antenatal screening.ResultsAmong the 49,479 gravidae in the cohort, the 1624 (3.3%) HBsAg seropositive gravidae had a lower incidence of nulliparity (RR 0.963, 95% CI 0.935–0.992) and having received tertiary education (RR 0.829, 95% CI 0.784–0.827). There was no significant difference in the medical history, pregnancy complications, or labor or perinatal outcome, except that HBV carriers had significantly lower incidence of labor induction (RR 0.827, 95% CI 0.714–0.958) and of small-for-gestational age (SGA) infants (RR 0.854, 95% CI 0.734–0.994). On regression analysis, maternal HBV carriage was independently associated with spontaneous labor (aRR 1.231, 95% CI 1.044–1.451) and reduced SGA infants (aRR 0.842, 95% CI 0.712–0.997).ConclusionsOur 3.3% prevalence of maternal HBV infection was around the lower range determined in the Chinese population. The association with spontaneous labor and reduced SGA infants could have helped to promote the perpetuation of the infection through enhanced survival of the offspring infected at birth, thus explaining the high prevalence in the Chinese population.
登录
查看更多内容
影响因子：
4.2
作者：
Bajema KL;Stankiewicz Karita HC;Tenforde MW;Hawes SE;Heffron R
通讯作者：
Heffron R
影响因子：
6.7
作者：
Connell, Laura E.;Salihu, Hamisu M.;Mbah, Alfred K.
通讯作者：
Mbah, Alfred K.
影响因子：
168.9
作者：
Schweitzer, Aparna;Horn, Johannes;Ott, Joerdis J.
通讯作者：
Ott, Joerdis J.
影响因子：
34.3
作者：
Liu, Jue;Zhang, Shikun;Zhang, Yiping
通讯作者：
Zhang, Yiping
影响因子：
2.4
作者：
Cui, Ai-Min;Shao, Jian-Guo;Cheng, Xiao-Yan
通讯作者：
Cheng, Xiao-Yan