Substrate recognition by TRIM and TRIM-like proteins in innate immunity.
Substrate recognition by TRIM and TRIM-like proteins in innate immunity.
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先天免疫中TRIM及类TRIM蛋白对底物的识别
DOI：
10.1016/j.semcdb.2020.09.013
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发表时间：
2021-03
影响因子：
7.3
通讯作者：
Hur S
中科院分区：
文献类型：
--
作者：
Wang HT;Hur S
TRIM（Tripartite motif）和TRIM样蛋白已经成为先天免疫中一类重要的E3连接酶。它们的功能范围从激活或调节先天免疫信号通路到直接检测和限制病原体。尽管重要性，许多TRIM/TRIM样蛋白的分子机制仍然很难表征，部分原因是鉴定其底物的挑战。本文就TRIM/TRIM样蛋白在RNA传感通路和病毒限制性内切酶中的作用进行综述。我们专注于那些含有PRY-SPRY，最常用于底物识别的结构域，并讨论了一些TRIM/TRIM样蛋白质通常用于严格控制其与底物相互作用的新兴机制。
TRIM (Tripartite motif) and TRIM-like proteins have emerged as an important class of E3 ligases in innate immunity. Their functions range from activation or regulation of innate immune signaling pathway to direct detection and restriction of pathogens. Despite the importance, molecular mechanisms for many TRIM/TRIM-like proteins remain poorly characterized, in part due to challenges of identifying their substrates. In this review, we discuss several TRIM/TRIM-like proteins in RNA sensing pathways and viral restriction functions. We focus on those containing PRY-SPRY, the domain most frequently used for substrate recognition, and discuss emerging mechanisms that are commonly utilized by several TRIM/TRIM-like proteins to tightly control their interaction with the substrates.
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