Cognitive Deficits in Prematurely Born Adults Are Associated With Reduced Basal Forebrain Integrity.
Cognitive Deficits in Prematurely Born Adults Are Associated With Reduced Basal Forebrain Integrity.
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DOI：
10.1016/j.biopsych.2017.04.004
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发表时间：
2017-07-15
影响因子：
10.6
通讯作者：
Balu DT
中科院分区：
文献类型：
--
作者：
Balu DT
众所周知，早产儿会增加出现不良长期后果的风险，包括神经认知缺陷。在本期中，Grothe 等人 (1) 研究了胆碱能基底前脑 (cBF) 发育受损是否会导致早产儿成年期间的认知缺陷。全世界范围内早产的发生率为 10%，并与许多不良的长期结果相关，包括较高的发病率、生长障碍和神经认知发育受损 (2)。那些出生体重极低（VLBW；< 1500 克）和/或极早产（VP；胎龄< 32 周）的人出现不良后果的风险显着增加 (3)。早产后的神经元扰动可能是由于围产期应激源（即缺血、缺氧和炎症）导致脑损伤的可能性较高。
It is well known that individuals born prematurely have increased risk for adverse long-term outcomes, including neurocognitive deficits. In this issue, Grothe et al.(1) investigate whether the impairments in the development of the cholinergic basal forebrain (cBF) contributes to cognitive deficits in premature born individuals during adulthood.Premature births occur at a worldwide rate of 10% and are associated with a host of adverse long-term outcomes, including higher morbidity, growth failure, and impaired neurocognitive development (2). Those born with very low birth weight (VLBW;< 1500 g) and/or very preterm (VP; gestational age,< 32 weeks) have a significantly increased risk for adverse outcomes (3). The neuronal perturbations following premature birth could be due to a higher propensity for brain injury as a result of perinatal stressors (ie, ischemia, hypoxia, and inflammation).
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DOI：
10.1038/npp.2010.104
发表时间：
2011-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.1
作者：
Ash JA;Velazquez R;Kelley CM;Powers BE;Ginsberg SD;Mufson EJ;Strupp BJ
通讯作者：
Strupp BJ
影响因子：
3.6
作者：
Isaacs, Elizabeth B.;Gadian, David G.;Lucas, Alan
通讯作者：
Lucas, Alan
影响因子：
11.2
作者：
JOHNSTON, MV
通讯作者：
JOHNSTON, MV
影响因子：
3.7
作者：
Grothe, Michel;Zaborszky, Laszlo;Cantero, Jose L.
通讯作者：
Cantero, Jose L.