Prenatal depression restricts fetal growth.
Prenatal depression restricts fetal growth.
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DOI：
10.1016/j.earlhumdev.2008.07.002
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发表时间：
2009-01
影响因子：
2.5
通讯作者：
Gonzalez-Quintero, Victor Hugo
中科院分区：
文献类型：
--
作者：
Diego, Miguel A.;Field, Tiffany;Hernandez-Reif, Maria;Schanberg, Saul;Kuhn, Cynthia;Gonzalez-Quintero, Victor Hugo
确定产前抑郁是否是胎儿生长受限的危险因素。妊娠中期（18-20周GA）估计胎儿体重和尿皮质醇和出生体重和胎龄出生时的数据收集的样本40抑郁症和40非抑郁症的妇女。然后使用估计的胎儿体重和出生体重数据计算胎儿生长率。抑郁女性的早产发生率比非抑郁女性高13%（比值比（OR）= 2.61），低出生体重发生率高15%（OR = 4.75）。抑郁的妇女也有产前皮质醇水平升高（p = 0.006）和胎儿较小（p = 0.001），胎儿生长速度较慢（p = 0.011）和出生体重较低（p = 0.008）。中介分析进一步显示，产前母体皮质醇水平是一个潜在的调解人之间的关系，母亲的抑郁症状和出生时的胎龄和胎儿生长速度。在控制了母体人口统计学变量后，产前母体皮质醇水平与出生时胎龄变化的30%和胎儿生长速度变化的14%相关。产前抑郁症与不良的围产期结局有关，包括早产和胎儿生长速度较慢。产前母体皮质醇水平似乎在调解这些结果中发挥作用。
To identify whether prenatal depression is a risk factor for fetal growth restriction. Midgestation (18-20 weeks GA) estimated fetal weight and urine cortisol and birth weight and gestational age at birth data were collected on a sample of 40 depressed and 40 non-depressed women. Estimated fetal weight and birthweight data were then used to compute fetal growth rates. Depressed women had a 13% greater incidence of premature delivery (Odds Ratio (OR) = 2.61) and 15% greater incidence of low birthweight (OR = 4.75) than non-depressed women. Depressed women also had elevated prenatal cortisol levels (p = .006) and fetuses who were smaller (p = .001) and who showed slower fetal growth rates (p = .011) and lower birthweights (p = .008). Mediation analyses further revealed that prenatal maternal cortisol levels were a potential mediator for the relationship between maternal symptoms of depression and both gestational age at birth and the rate of fetal growth. After controlling for maternal demographic variables, prenatal maternal cortisol levels were associated with 30% of the variance in gestational age at birth and 14% of the variance in the rate of fetal growth. Prenatal depression was associated with adverse perinatal outcomes, including premature delivery and slower fetal growth rates. Prenatal maternal cortisol levels appear to play a role in mediating these outcomes.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1196/annals.1365.047
发表时间：
2006-01-01
期刊：
WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC, ENDOCRINE, AND REPRODUCTIVE ISSUES
影响因子：
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作者：
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通讯作者：
Nicolaides, Kypros
影响因子：
0.9
作者：
HILL, LM;BRECKLE, R;OBRIEN, PC
通讯作者：
OBRIEN, PC
影响因子：
6
作者：
Jauniaux, E;Watson, AL;Burton, GJ
通讯作者：
Burton, GJ
DOI：
10.1016/s0002-9378(97)70572-6
发表时间：
1997-03-01
影响因子：
9.8
作者：
Jaffe, R;Jauniaux, E;Hustin, J
通讯作者：
Hustin, J