Left ventricular volume during supine exercise: importance of myocardial scar in patients with coronary heart disease.
Left ventricular volume during supine exercise: importance of myocardial scar in patients with coronary heart disease.
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仰卧运动时的左心室容量：心肌疤痕对冠心病患者的重要性。
DOI：
10.1016/s0735-1097(87)80077-3
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发表时间：
1987
影响因子：
24
通讯作者：
Gilpin,E
中科院分区：
文献类型：
--
作者：
Mann,DL;Scharf,J;Ahnve,S;Gilpin,E
现有的研究表明，运动诱导的缺血会增加左室舒张末容量；然而，所有这些研究都包括了既往有心肌梗死史的患者。为了检验运动对舒张末容量的反应是否与心肌瘢痕的程度有关，我们回顾了130名受试者的门控核素仰卧位运动试验结果。患者组包括130名年龄在35岁到65岁之间的男性，平均年龄为52±5岁，有病史的冠心病患者。根据运动高峰时左室舒张末容量反应将患者分为3组：第1组(72例)舒张末容量增加>10%，第2组(41例)舒张末容量变化<10%，第3组(17例)舒张末容量减少>10%(n=17)。安静时，两组在心率、收缩压、舒张期末期(EDVrest)、收缩末期容量或射血分数方面没有显著差异(p>；0.002)；然而，在运动高峰时，第一组收缩末期容量反应明显更大(p<；0.05)。方差分析显示，第1组(−1.24±1.1 mV)、第2组(−0.91±1.0 mV)和第3组(−0.75±0.9 mV)运动后ST段压低的程度差异无统计学意义(p>；0.05)，第1组(4.1±4.5)、第2组(3.4±4.1)和第3组(2.5±2.8)Tl-201“缺血评分”差异无统计学意义(P>0.05)。Tl-201“瘢痕评分”(SCAR)在三组间分别为13.9±7.1、10.6±6.7和9.5±4.8，差异有统计学意义(P<；0.01)。多元线性回归分析表明，舒张末容积(%EDV)的变化可用方程：%EDV=1.5[SCAR]−0.22[峰收缩压]−0.29[EDVREST]+81.6(r=0.49，p<；0.0001)来描述。
Existing studies suggest that exercise-induced ischemia produces an increase in left ventricular end-diastolic volume; however, all of these studies have included patients with previous myocardial infarction. To test whether the end-diastolic volume response to exercise is related to the extent of myocardial scar, the results of gated radionuclide supine exercise tests performed on 130 subjects were reviewed. The patient group comprised 130 men aged 35 to 65 years (mean ± SD 52 ± 5) with documented coronary heart disease. The extent of myocardial ischemia and scar formation was assessed by stress electrocardiography and thallium-201 scintigraphy.Patients were classified into three groups on the basis of left ventricular end-diastolic volume response at peak exercise: group 1 (n = 72) had an increase of end-diastolic volume greater than 10%, group 2 (n = 41) had a change in end-diastolic volume less than 10% and group 3 (n = 17) had a decrease in end-diastolic volume greater than 10% (n = 17). At rest there was no significant difference among groups in heart rate, systolic blood pressure, end-diastolic (EDVrest) or end-systolic volumes or ejection fraction (p > 0.05); however, at peak exercise the end-systolic volume response was significantly greater for group 1 (p < 0.002). Analysis of variance revealed no significant difference (p > 0.05) in the extent of exercise-induced lateral ST segment depression among group 1 (−1.24 ± 1.1 mV), group 2 (−0.91 ± 1.0 mV) or group 3 (−0.75 ± 0.9 mV), or the thallium-201 “ischemia scores” among group 1 (4.1 ± 4.5), group 2(3.4 ± 4.1) or group 3 (2.5 ± 2.8). Thallium-201 “scar scores” (SCAR), however, were significantly different (p < 0.01) among the three groups 13.9 ± 7.1, 10.6 ± 6.7 and 9.5 ± 4.8, respectively. Multivariate linear regression analysis indicated that the percent change in end-diastolic volume (%EDV) was best described by the equation: %EDV = 1.5[scar] −0.22[peak systolic blood pressure] −0.29[EDVrest] + 81.6 (r = 0.49, p < 0.0001).These data suggest that in men, exercise-induced changes in end-diastolic volume during supine exercise are related to the extent of myocardial scar.
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通过放射性核素平衡血管造影评估男性左心室容积对运动的反应
影响因子：
37.8
作者：
R. Slutsky;J. Karliner;D. Ricci;G. Schuler;M. Pfisterer;K. Peterson;W. Ashburn
通讯作者：
W. Ashburn
定量放射性核素血管造影评估直立运动期间血流动力学变化：在正常受试者、冠状动脉疾病患者和主动脉瓣反流患者中的观察。
DOI：
10.1016/0002-9149(81)90602-0
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
--
作者：
A. Iskandrian;A. Hakki;S. Kane;Bernard L. Segal
通讯作者：
Bernard L. Segal
实验性梗塞中铊 201 心肌摄取的病理生理学相关性。
影响因子：
10.8
作者：
V. Dicola;S. Downing;R. Donabedian;B. L. Zaret
通讯作者：
B. L. Zaret
通过放射性核素血管造影评价正常人和慢性冠心病患者运动时的左心室功能。
影响因子：
24
作者：
A. Iskandrian;A. Hakki;N. DePace;B. Manno;Segal Bl
通讯作者：
Segal Bl
起搏引起的缺血对冠状动脉狭窄犬左心室舒张压-容积关系的影响
影响因子：
20.1
作者：
T. Serizawa;B. Carabello;W. Grossman
通讯作者：
W. Grossman