Plastid signalling under multiple conditions is accompanied by a common defect in RNA editing in plastids.
Plastid signalling under multiple conditions is accompanied by a common defect in RNA editing in plastids.
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DOI：
10.1093/jxb/err257
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发表时间：
2012-01
影响因子：
6.9
通讯作者：
Inaba T
中科院分区：
文献类型：
--
作者：
Kakizaki T;Yazu F;Nakayama K;Ito-Inaba Y;Inaba T
从质体到核的逆行信号传导，也称为质体信号传导，在协调核基因表达与质体功能状态中起关键作用。已提出引起质体功能障碍的抑制剂产生与其作用模式相关的特异性质体信号。然而，参与质体信号传导的分子仍有待鉴定。遗传研究表明，质体定位的五肽重复蛋白GUN 1介导的信号在几个质体信号相关的条件下。为了进一步阐明质体信号的性质，进行了调查，以确定是否不同的质体信号诱导处理对质体和核基因表达具有类似的影响。结果表明，氟草松和林可霉素治疗和质体蛋白导入2 -2（ppi 2 -2）突变，这导致质体蛋白导入的缺陷，都导致了类似的基因表达水平的变化。此外，观察到这三种处理导致质体中有缺陷的RNA编辑。RNA编辑中的这种缺陷不是细胞核中五肽重复蛋白基因表达下调的继发效应。结果表明，已知诱导质体信号的这三种处理影响质体中的RNA编辑，表明质体信号和RNA编辑之间存在前所未有的联系。
Retrograde signalling from the plastid to the nucleus, also known as plastid signalling, plays a key role in coordinating nuclear gene expression with the functional state of plastids. Inhibitors that cause plastid dysfunction have been suggested to generate specific plastid signals related to their modes of action. However, the molecules involved in plastid signalling remain to be identified. Genetic studies indicate that the plastid-localized pentatricopeptide repeat protein GUN1 mediates signalling under several plastid signalling-related conditions. To elucidate further the nature of plastid signals, investigations were carried out to determine whether different plastid signal-inducing treatments had similar effects on plastids and on nuclear gene expression. It is demonstrated that norflurazon and lincomycin treatments and the plastid protein import2-2 (ppi2-2) mutation, which causes a defect in plastid protein import, all resulted in similar changes at the gene expression level. Furthermore, it was observed that these three treatments resulted in defective RNA editing in plastids. This defect in RNA editing was not a secondary effect of down-regulation of pentatricopeptide repeat protein gene expression in the nucleus. The results indicate that these three treatments, which are known to induce plastid signals, affect RNA editing in plastids, suggesting an unprecedented link between plastid signalling and RNA editing.
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影响因子：
64.8
作者：
BRADBEER, JW;ATKINSON, YE;HAGEMANN, R
通讯作者：
HAGEMANN, R
影响因子：
7.4
作者：
Kakizaki, Tomohiro;Matsumura, Hideo;Inaba, Takehito
通讯作者：
Inaba, Takehito
影响因子：
11.6
作者：
Hammani, Kamel;Okuda, Kenji;Small, Ian
通讯作者：
Small, Ian
影响因子：
4.2
作者：
Morris, DA
通讯作者：
Morris, DA
影响因子：
5.1
作者：
CHAMOVITZ, D;PECKER, I;HIRSCHBERG, J
通讯作者：
HIRSCHBERG, J