Human Responses to Visually Evoked Threat.
Human Responses to Visually Evoked Threat.
复制标题
DOI：
10.1016/j.cub.2020.11.035
复制
发表时间：
2021-02-08
期刊：
影响因子：
--
通讯作者：
Huberman AD
中科院分区：
文献类型：
--
作者：
Yilmaz Balban M;Cafaro E;Saue-Fletcher L;Washington MJ;Bijanzadeh M;Lee AM;Chang EF;Huberman AD
视觉是人类用来评估和应对威胁的主要感觉。了解人类威胁反应的生物学基础一直受到缺乏现实的实验室威胁范例的阻碍。我们建立了一个沉浸式虚拟现实（VR）平台，使用长期植入的电极同时测量人类大脑的行为，生理状态和神经活动。与健康对照组相比，高度焦虑的受试者对威胁的视觉扫描增加。在健康和焦虑的受试者中，扫描行为的数量与生理唤醒的程度相关，这表明视觉扫描行为与内部状态直接相关。三名受试者的颅内脑电图（iEEG）记录表明，大脑皮层的高频γ活动与视觉威胁引起的生理唤醒呈正相关，而眶额皮质（OFC）的低频θ活动与视觉威胁引起的生理唤醒呈负相关。这些研究结果揭示了眼动的关键作用，并表明，不同的眼动和OFC激活动态可能是重要的检测和调整人类的压力，在视觉感知的威胁。Yilmaz Balban等人使用行为、生理和神经记录来研究人类对视觉威胁的反应。他们证明，暴露在虚拟高度触发视觉扫描行为成比例的自主觉醒反应。岛叶和眶额皮质与视觉驱动的觉醒有显著的相关性。
Vision is the primary sense humans use to evaluate and respond to threats. Understanding the biological underpinnings of the human threat response has been hindered by lack of realistic in-lab threat paradigms. We established an immersive virtual reality (VR) platform to simultaneously measure behavior, physiological state, and neural activity from the human brain using chronically implanted electrodes. Subjects with high anxiety showed increased visual scanning in response to threats as compared to healthy controls. In both healthy and anxious subjects, the amount of scanning behavior correlated with the magnitude of physiological arousal, suggesting that visual scanning behavior is directly linked to internal state. Intracranial electroencephalography (iEEG) recordings from three subjects suggested that high-frequency gamma activity in the insula positively correlates with physiological arousal induced by visual threats and that low-frequency theta activity in the orbitofrontal cortex (OFC) negatively correlates with physiological arousal induced by visual threats. These findings reveal a key role of eye movements and suggest that distinct insula and OFC activation dynamics may be important for detecting and adjusting human stress in response to visually perceived threats. Yilmaz Balban et al. investigate human responses to visual threats using behavioral, physiological, and neural recordings. They demonstrate that exposure to virtual heights triggers visual scanning behavior proportional to the autonomic arousal response. Insula and orbitofrontal cortex show significant correlations with visually driven arousal.
登录
查看更多内容
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
--
作者：
Estes, WK;Skinner, BF
通讯作者：
Skinner, BF
影响因子：
16.2
作者：
Adhikari, Avishek;Topiwala, Mihir A.;Gordon, Joshua A.
通讯作者：
Gordon, Joshua A.
影响因子：
1.3
作者：
Allcoat, Devon;Greville, W. James;Dymond, Simon
通讯作者：
Dymond, Simon
影响因子：
9.2
作者：
Bach, Dominik R.;Guitart-Masip, Marc;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.