Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety.
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety.
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DOI：
10.1016/j.neuron.2009.12.002
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发表时间：
2010-01-28
期刊：
影响因子：
16.2
通讯作者：
Gordon, Joshua A.
中科院分区：
文献类型：
--
作者：
Adhikari, Avishek;Topiwala, Mihir A.;Gordon, Joshua A.
腹侧海马体与背侧海马体不同，它是焦虑样行为所必需的。它的行动方式尚不清楚。我们假设海马体与影响焦虑的下游靶点（如内侧前额叶皮层（mPFC））相连。为了验证这一假设，我们记录了暴露于两种致焦虑区域的小鼠的mPFC和海马活动。在基线时，mPFC和腹侧海马体的θ频率活动高度相关，而背侧海马体则不相关，并且这种相关性在两种致焦虑环境中都有所增加。mPFC θ功率的增加预示着回避每个竞技场的厌恶区室，并且在5-羟色胺1A受体敲除小鼠中更大，这是一种焦虑样行为增加的遗传模型。这些结果表明腹侧海马和mPFC之间的θ频率同步在焦虑中的作用。他们是一致的概念，这种同步是一种普遍的机制，海马体与下游结构的行为相关性。
The ventral hippocampus, unlike its dorsal counterpart, is required for anxiety-like behavior. The means by which it acts are unknown. We hypothesized that the hippocampus synchronizes with downstream targets that influence anxiety, such as the medial prefrontal cortex (mPFC). To test this hypothesis, we recorded mPFC and hippocampal activity in mice exposed to two anxiogenic arenas. Theta-frequency activity in the mPFC and ventral, but not dorsal hippocampus was highly correlated at baseline, and this correlation increased in both anxiogenic environments. Increases in mPFC theta power predicted avoidance of the aversive compartments of each arena, and were larger in serotonin 1A-receptor knockout mice, a genetic model of increased anxiety-like behavior. These results suggest a role for theta-frequency synchronization between the ventral hippocampus and the mPFC in anxiety. They are consistent with the notion that such synchronization is a general mechanism by which the hippocampus communicates with downstream structures of behavioral relevance.
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DOI：
10.1097/01.alc.0000141809.53115.71
发表时间：
2004-10-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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影响因子：
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影响因子：
2.9
作者：
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通讯作者：
Hernandez, L
DOI：
10.1073/pnas.172091899
发表时间：
2002-08-20
影响因子：
11.1
作者：
Barrot, M;Olivier, JDA;Nestler, EJ
通讯作者：
Nestler, EJ