The potential role of neopterin in Covid-19: a new perspective.
The potential role of neopterin in Covid-19: a new perspective.
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DOI：
10.1007/s11010-021-04232-z
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发表时间：
2021-11
影响因子：
4.3
通讯作者：
Batiha GE
中科院分区：
文献类型：
--
作者：
Al-Kuraishy HM;Al-Gareeb AI;Alzahrani KJ;Cruz-Martins N;Batiha GE
新蝶呤（NPT）是蝶啶类化合物中的一员，在干扰素γ (INF-γ)刺激下由巨噬细胞合成。NPT被认为是巨噬细胞刺激指标、细胞免疫激活和T辅助1 （Th1）型免疫应答的标志物。在此，我们就《不扩散核武器条约》的特点及其在应对新冠疫情中的作用谈几点看法。血清NPT水平被认为是Covid-19严重程度的独立预后因素，从SARS-CoV-2感染的第3天开始升高，与严重呼吸困难、住院时间延长和并发症相关。此外，NPT的早期升高反映了抗体免疫反应之前单核/巨噬细胞的激活，尽管在Covid-19患者中或在出现临床症状之前的潜伏期结束时，NPT水平也可能保持较高水平。另一方面，NPT减弱巨噬细胞泡沫细胞的活性，并通过抑制粘附分子和单核细胞迁移与内皮炎症有关。然而，NPT还通过抑制NF-κB信号传导和NLRP3炎症小体发挥抗炎和抗氧化作用。NPT可被视为一种保护性代偿机制，以平衡过度炎症、氧化应激和相关的器官损伤。
Neopterin (NPT) is a member of pteridines group, synthesized by macrophages when stimulated by interferon gamma (INF-γ). NPT is regarded as a macrophage stimulation indicator, marker of cellular immune activation and T helper 1 (Th1) type 1 immune response. Here, we aimed to provide a view point on the NPT features and role in Covid-19. Serum NPT level is regarded as an independent prognostic factor for Covid-19 severity, with levels starting to increase from the 3rd day of SARS-CoV-2 infection, being associated with severe dyspnea, longer hospitalization period and complications. Also, early raise of NPT reflects monocytes/macrophages activation before antibody immune response, despite the NPT level may also remain high in Covid-19 patients or at the end of incubation period before the onset of clinical symptoms. On the other hand, NPT attenuates the activity of macrophage foam cells and is linked to endothelial inflammation through inhibition of adhesion molecules and monocytes migration. However, NPT also exerts anti-inflammatory and antioxidant effects by suppressing NF-κB signaling and NLRP3 inflammasomes. NPT can be viewed as a protective compensatory mechanism to counterpoise hyper-inflammation, oxidative stress, and associated organ damage.
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影响因子：
3.4
作者：
El-Lebedy, Dalia;Hussein, Jihan;Mohammed, Asmaa M.
通讯作者：
Mohammed, Asmaa M.
影响因子：
1.4
作者：
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通讯作者：
Lungnier, Claire
DOI：
10.1016/j.diagmicrobio.2007.04.019
发表时间：
2007-10-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
1.4
作者：
Al-Kuraishy, Hayder;Hussien, Nawar;Lungnier, Claire
通讯作者：
Lungnier, Claire
影响因子：
3.2
作者：
Al-Kuraishy HM;Al-Gareeb AI;Qusty N;Cruz-Martins N;El-Saber Batiha G
通讯作者：
El-Saber Batiha G