Diffusion‐weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat
Diffusion‐weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat
复制标题
扩散加权磁共振成像检测大鼠四血管闭塞缺血后的早期神经病理学
DOI：
10.1002/jmri.1175
复制
发表时间：
2001
影响因子：
4.4
通讯作者：
Steven Williams
中科院分区：
文献类型：
--
作者：
Lloyd J. Gregory;Lloyd J. Gregory;Michael J. O'Neill;J. A. Nunn;Joanna Gray;Steven Williams
使用磁共振成像（MRI）绘制大鼠四血管闭塞（4vo）缺血后的早期神经病理学图。动物在体内评估前接受30分钟的4 VO （N = 6）或假手术（N = 6）。在结扎后6小时、24小时和72小时进行质子密度和T2以及T2/扩散加权（T2/DW）联合MRI检查。T2/DW成像是区分损伤组织和完整组织的最有效序列，显示了缺血后24小时背外侧纹状体和72小时海马CA1/CA2亚区的神经病理。纹状体（P = 0.03）和海马（P = 0.005）的表观扩散系数值分别在24和72小时显著降低。据我们所知，这是第一个T2/DW成像检测4 VO后病变符合已知的缺血性脑损伤时间演变的报告。j .增效。的原因。成像2001;14:207 - 214。©2001 Wiley‐Liss, Inc。
Early neuropathology following a prolonged duration of four‐vessel occlusion (4 VO) ischemia in the rat was charted using magnetic resonance imaging (MRI). Animals received either 30 minutes of 4 VO (N = 6) or sham operation (N = 6) prior to in vivo assessment. Proton density and T2 and combined T2/diffusion‐weighted (T2/DW) MRI were performed at 6, 24, and 72 hours postocclusion. T2/DW imaging was the most effective sequence for delineating between injured and intact tissues, indicating neuropathology in the dorsolateral striatum at 24 hours and in the CA1/CA2 subfields of the hippocampus at 72 hours following ischemia. Apparent diffusion coefficient values were significantly reduced in the striatum (P = 0.03) and hippocampus (P = 0.005) at 24 and 72 hours, respectively. This is the first report, to our knowledge, of T2/DW imaging detecting lesions following 4 VO in accord with the known temporal evolution of ischemic brain damage. J. Magn. Reson. Imaging 2001;14:207–214. © 2001 Wiley‐Liss, Inc.
影响因子：
8.3
作者：
WELCH, KMA;WINDHAM, J;LEVINE, SR
通讯作者：
LEVINE, SR
影响因子：
8.3
作者：
PEREZTREPICHIO, AD;XUE, M;JONES, SC
通讯作者：
JONES, SC
海马体中 NGF 依赖性发芽和再生。
影响因子：
--
作者：
Gage,FH;Buzsáki,G;Armstrong,DM
通讯作者：
Armstrong,DM