Amniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate.
Amniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate.
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DOI：
10.1002/sctm.18-0018
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发表时间：
2018-11
影响因子：
6
通讯作者：
Kunisaki SM
中科院分区：
文献类型：
--
作者：
Kunisaki SM
在过去的十年中，羊水来源的干细胞已经成为一种新的实验方法，旨在改善先天性异常儿童的结局，包括脊柱裂，心脏缺陷和疝气。对这些细胞用于治疗产前诊断疾病的兴趣已经基于许多研究而产生，这些研究证明了从少量液体中收获大量巨噬细胞的相对容易性，巨噬细胞本身的独特性质，以及羊水来源的干细胞在实验动物模型中的有益作用。本报告简要概述了羊水干细胞治疗的原理和现状，重点关注其与影响胎儿和新生儿的出生缺陷的相关性。作者提出了羊水干细胞技术临床应用前需要进一步研究的路线图。干细胞转化医学2018;7：767-773
Over the past decade, amniotic fluid‐derived stem cells have emerged as a novel experimental approach aimed at improving outcomes in children with congenital anomalies, including spina bifida, heart defects, and diaphragmatic hernia. Interest in these cells for the treatment of prenatally diagnosed diseases has arisen based on numerous studies demonstrating the relative ease of harvesting an abundant quantity of amniocytes from a small aliquot of fluid, the unique properties of amniocytes themselves, and the beneficial effects of amniotic fluid‐derived stem cells in experimental animal models. This report gives a brief overview of the rationale and current status of amniotic fluid stem cell‐based therapies, focusing on its relevance to birth defects affecting the fetus and neonate. The author proposes a roadmap for further study that would be required prior to clinical application of amniotic fluid stem cell technologies. stem cells translational medicine 2018;7:767–773
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