Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors.
Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors.
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人类T-淋巴细胞性病毒类型和II感染的前献血者中的重度抑郁症和普遍的焦虑症。
DOI：
10.1111/j.1537-2995.2012.03677.x
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发表时间：
2013-01
期刊：
影响因子：
2.9
通讯作者：
HTLV Outcomes Study (HOST)
中科院分区：
文献类型：
--
作者：
Guiltinan AM;Kaidarova Z;Behan D;Marosi C;Hutching S;Kaiser M;Moore E;Devita D;Murphy EL;HTLV Outcomes Study (HOST)
其他研究报告了人类嗜T淋巴细胞病毒1型（HTLV-1）感染受试者中抑郁和焦虑的高发病率，甚至表明HTLV-1会导致精神疾病。我们采访了HTLV-I，HTLV-II和人口统计学上相似的HTLV血清阴性献血者与迷你国际神经精神访谈（MINI）。研究人员计算了各组中重度抑郁症和广泛性焦虑症的患病率，并将其与已发表的美国人口数据进行了比较。校正后的优势比（aOR）和95%置信区间（95%CI）控制的教育成就，饮酒和自我报告的健康状况进行了多变量logistic回归计算。在93名HTLV-I阳性受试者中有5名（5.4%）（aOR = 2.19，95%CI 0.63-7.55）和256名HTLV-II阳性受试者中有17名（6.6%）（aOR = 1.61，95%CI 0.66-3.927）被诊断为重度抑郁症，而在585名HTLV血清阴性献血者中有12名（2.1%）被诊断为重度抑郁症。受感染受试者中重度抑郁症的患病率与美国普通人群的6.7%患病率相当。广泛性焦虑症在5名（5.4%）HTLV-I阳性受试者（OR= 2.32，95% CI 0.74-7.26）和12名（4.7%）HTLV-II阳性受试者（OR = 1.65，95% CI 0.68-4.01）中被诊断，而在美国一般人群中，血清阴性受试者和3.1%被诊断。在控制了健康状况和其他混杂变量后，HTLV-I和HTLV-II感染的前献血者中重度抑郁症和广泛性焦虑症的患病率并没有显著增加。HTLV血清阴性献血者的这些疾病的患病率低于美国人群，可能是由于“健康献血者效应”。
Other studies have reported high rates of depression and anxiety among human T-lymphotropic virus type 1 (HTLV-1) infected subjects, and have even suggested that HTLV-I causes psychiatric disease. We interviewed HTLV-I, HTLV-II and demographically similar HTLV seronegative blood donors with the Mini-International Neuropsychiatric Interview (MINI). Prevalences of major depression and generalized anxiety disorder in each group were calculated and compared to published U.S. population data. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) controlling for educational achievement, alcohol intake and self-reported health status were calculated with multivariate logistic regression. Major depression was diagnosed in 5 (5.4%) of 93 HTLV-I positive subjects (aOR = 2.19, 95% CI 0.63–7.55) and 17 (6.6%) of 256 HTLV-II positive subjects (aOR = 1.61, 95% CI 0.66–3.927), compared to 12 (2.1%) of 585 HTLV seronegative blood donors. The prevalence of major depression among infected subjects was comparable to the 6.7% prevalence in the U.S. general population. Generalized anxiety disorder was diagnosed in 5 (5.4%) HTLV-I positive subjects (OR= 2.32, 95% CI 0.74–7.26) and 12 (4.7%) HTLV-II positive subjects (OR = 1.65 95% CI 0.68–4.01), compared to 15 (2.6%) seronegatives and 3.1% in the U.S. general population. Major depression and generalized anxiety disorder were not significantly more prevalent among HTLV-I and HTLV-II infected former blood donors after controlling for health status and other confounding variables. HTLV seronegative blood donors had lower prevalence of these conditions than the U.S. population, probably due to a “healthy blood donor effect”.
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影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
4.6
作者：
Rabkin, Judith G
通讯作者：
Rabkin, Judith G
影响因子：
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作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
6.7
作者：
Basseri, Benjamin;Yamini, David;Poordad, Fred
通讯作者：
Poordad, Fred
影响因子：
4.4
作者：
Andrade, L;Walters, EE;Laurenti, R
通讯作者：
Laurenti, R