Race, APOE genotypes, and cognitive decline among middle-aged urban adults.
Race, APOE genotypes, and cognitive decline among middle-aged urban adults.
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DOI：
10.1186/s13195-021-00855-y
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发表时间：
2021-06-30
期刊：
影响因子：
--
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Weiss J;Beydoun HA;Hossain S;Maldonado AI;Shen B;Evans MK;Zonderman AB
载脂蛋白 (APOE) ε2 或 ε4（APOE2 或 APOE4）剂量与认知变化的关联可能因种族群体而异。 1770 名中年白人和非裔美国成年人的纵向数据来自“一生中多样性社区的健康老龄化”（HANDLS 2004-2013）研究。 APOE2 和 APOE4 剂量是两种主要暴露，而 v1 和 11 项测试分数的认知表现年变化率（v1 和 v2 之间）是主要关注结果（v1：2004-2009 年和 v2：2009-2013 年）。混合效应线性回归模型针对社会人口、生活方式和健康相关的潜在混杂因素进行了调整。种族（非裔美国人与白人）和种族群体内的性别是主要影响因素。经过对多项测试和潜在混杂因素的调整后，仅在白人中，APOE4 等位基因剂量与言语记忆测试中的更快下降相关（CVLT-列表 A：γ12 = − 0.363 ± 0.137，p = 0.008），但在非裔美国人中则不然。相比之下，在非裔美国女性中，APOE4 剂量与注意力测试中较慢的下降有关（BTA：γ12 = + 0.106 ± 0.035，p = 0.002），而在非裔美国男性中没有发现任何关联。 APOE2 和 APOE4 剂量在整体认知的其他领域和跨种族群体中显示出不一致的结果，无法通过多重测试的校正。总之，仅在白人中，APOE4 剂量与言语记忆测试中的更快下降有关，同时在非裔美国女性的注意力领域表现出潜在的保护作用。需要进一步的纵向研究来复制我们针对种族和性别的研究结果。在线版本包含可在 10.1186/s13195-021-00855-y 获取的补充材料。
Associations of Apolipoprotein (APOE) ε2 or ε4 (APOE2 or APOE4) dosages with cognitive change may differ across racial groups. Longitudinal data on 1770 middle-aged White and African American adults was compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS 2004-2013) study. APOE2 and APOE4 dosages were the two main exposures, while v1 and annual rate of change in cognitive performance (between v1 and v2) on 11 test scores were the main outcomes of interest (v1: 2004–2009 and v2: 2009–2013). Mixed-effects linear regression models were conducted adjusting for socio-demographic, lifestyle, and health-related potential confounders. Race (African American vs. White) and sex within racial groups were main effect modifiers. Upon adjustment for multiple testing and potential confounders, APOE4 allelic dosage was associated with faster decline on a test of verbal memory among Whites only (CVLT-List A: γ12 = − 0.363 ± 0.137, p = 0.008), but not among African Americans. In contrast, among African American women, APOE4 dosage was linked to slower decline on a test of attention (BTA: γ12 = + 0.106 ± 0.035, p = 0.002), while no association was detected among African American men. APOE2 and APOE4 dosages showed inconsistent results in other domains of cognition overall and across racial groups that did not survive correction for multiple testing. In conclusion, APOE4 dosage was associated with faster decline on a test of verbal memory among Whites only, while exhibiting a potential protective effect among African American women in the domain of attention. Further longitudinal studies are needed to replicate our race and sex-specific findings. The online version contains supplementary material available at 10.1186/s13195-021-00855-y.
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影响因子：
4.2
作者：
Beydoun MA;Boueiz A;Abougergi MS;Kitner-Triolo MH;Beydoun HA;Resnick SM;O'Brien R;Zonderman AB
通讯作者：
Zonderman AB
DOI：
10.1016/j.jalz.2018.04.010
发表时间：
2018-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Buckley RF;Mormino EC;Amariglio RE;Properzi MJ;Rabin JS;Lim YY;Papp KV;Jacobs HIL;Burnham S;Hanseeuw BJ;Doré V;Dobson A;Masters CL;Waller M;Rowe CC;Maruff P;Donohue MC;Rentz DM;Kirn D;Hedden T;Chhatwal J;Schultz AP;Johnson KA;Villemagne VL;Sperling RA;Alzheimer's Disease Neuroimaging Initiative;Australian Imaging, Biomarker and Lifestyle study of ageing;Harvard Aging Brain Study
通讯作者：
Harvard Aging Brain Study
影响因子：
9.9
作者：
Beydoun, May A.;Shaked, Danielle;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
9.9
作者：
Bretsky, P;Guralnik, JM;Seeman, TE
通讯作者：
Seeman, TE
影响因子：
11
作者：
Conejero-Goldberg, C.;Gomar, J. J.;Goldberg, T. E.
通讯作者：
Goldberg, T. E.