Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5.
Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5.
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DOI：
10.1177/0192623317728134
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发表时间：
2017-08
影响因子：
1.5
通讯作者：
Elmore SA
中科院分区：
文献类型：
--
作者：
Chen VS;Morrison JP;Southwell MF;Foley JF;Bolon B;Elmore SA
发育中的小鼠中枢神经系统（CNS）的评价提出了独特的挑战，因为个体发育的复杂性，每小时在三维空间中非常短的距离内进行显著的结构重组，以及许多易受遗传和环境影响的发育事件。影响脑和脊髓的发育缺陷经常在子宫内和围产期作为致畸剂暴露后的自发事件和诱导突变的后遗症出现，因此是许多小鼠模型中胚胎和围产期致死的常见因素。在小鼠的整个生命周期中，正常器官和细胞结构和分化的知识对于识别和表征神经发育病变至关重要。通过提供一个很好的说明概述总结在子宫内和围产期小鼠中枢神经系统正常发育的主要事件与常见的发育异常的例子，这注释，彩色图谱可用于识别正常的结构和组织学时，表型遗传工程小鼠（GEM），并将加强努力，以描述和解释脑和脊髓畸形的原因，小鼠胚胎和围产期致死表型。本图集中的示意图和图像说明了从胚胎第7.5天（E）到E18.5天的妊娠期间和从出生后第1天（P）到P21天的出生后的主要发育事件。
Evaluation of the central nervous system (CNS) in the developing mouse presents unique challenges given the complexity of ontogenesis, marked structural reorganization over very short distances in three dimensions each hour, and numerous developmental events susceptible to genetic and environmental influences. Developmental defects affecting the brain and spinal cord arise frequently both in utero and perinatally as spontaneous events, following teratogen exposure, and as sequelae to induced mutations, and thus are a common factor in embryonic and perinatal lethality in many mouse models. Knowledge of normal organ and cellular architecture and differentiation throughout the mouse’s lifespan is crucial to identify and characterize neurodevelopmental lesions. By providing a well-illustrated overview summarizing major events of normal in utero and perinatal mouse CNS development with examples of common developmental abnormalities, this annotated, color atlas can be used to identify normal structure and histology when phenotyping genetically engineered mice (GEM) and will enhance efforts to describe and interpret brain and spinal cord malformations as causes of mouse embryonic and perinatal lethal phenotypes. The schematics and images in this atlas illustrate major developmental events during gestation from embryonic day (E) 7.5 to E18.5 and after birth from postnatal day (P)1 to P21.
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DOI：
10.1002/bdra.20468
发表时间：
2008-07-01
影响因子：
--
作者：
Boulet, Sheree L.;Yang, Quanhe;Mulinare, Joe
通讯作者：
Mulinare, Joe
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
4.1
作者：
BANIK, NL;SMITH, ME
通讯作者：
SMITH, ME
影响因子：
30.8
作者：
Belloni, E;Muenke, M;Scherer, SW
通讯作者：
Scherer, SW
影响因子：
4.3
作者：
Brann JH;Firestein SJ
通讯作者：
Firestein SJ