Shedding light on nanomedicine.
Shedding light on nanomedicine.
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散发纳米医学的光。
DOI:
10.1002/wnan.1188
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发表时间:
2012-11
影响因子:
8.6
通讯作者:
Kohane, Daniel S.
中科院分区:
文献类型:
--
作者:
Tong, Rong;Kohane, Daniel S.
Light is electromagnetic radiation that can convert its energy into different forms (e.g., heat, chemical energy, and acoustic waves). This property has been exploited in phototherapy (e.g., photothermal therapy and photodynamic therapy) and optical imaging (e.g., fluorescence imaging) for therapeutic and diagnostic purposes. Light-controlled therapies can provide minimally or non-invasive spatiotemporal control as well as deep tissue penetration. Nanotechnology provides a numerous advantages, including selective targeting of tissues, prolongation of therapeutic effect, protection of active payloads, and improved therapeutic indices. This review explores the advances that nanotechnology can bring to light-based therapies and diagnostics, and vice versa, including photo-triggered systems, nanoparticles containing photoactive molecules, and nanoparticles that are themselves photoactive. Limitations of light-based therapies such as photic injury and phototoxicity will be discussed.
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