Delayed Computed Tomography Arthrography of Human Knee Cartilage In Vivo.
Delayed Computed Tomography Arthrography of Human Knee Cartilage In Vivo.
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DOI：
10.1177/1947603512447300
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发表时间：
2012-10
期刊：
影响因子：
2.8
通讯作者：
Töyräs J
中科院分区：
文献类型：
--
作者：
Kokkonen HT;Aula AS;Kröger H;Suomalainen JS;Lammentausta E;Mervaala E;Jurvelin JS;Töyräs J
我们研究了延迟计算机断层扫描（CT）关节造影术在体内评估人类膝关节软骨的可行性。特别是，确定了造影剂从关节空间的扩散和成像的最佳时间点。使用延迟 CT 关节造影和延迟钆增强软骨磁共振成像 (dGEMRIC) 技术对两名患者进行了成像。注射后两小时，关节间隙中造影剂的浓度仍然足够高（0 分钟时初始浓度的 20% 至 24.5%），可以进行延迟 CT 关节造影。造影剂在关节间隙的半衰期为 30 至 60 分钟。髌骨和股骨软骨中的造影剂浓度分别在30分钟和60分钟后达到最大值。根据 dGEMRIC，患者之间没有差异。然而，在延迟 CT 关节造影中，骨关节炎膝关节软骨中造影剂的渗透性较高。造影剂在关节间隙中保留足够长的时间，以便能够对软骨进行延迟 CT 关节造影。 30 分钟后，与健康膝关节相比，骨关节炎膝关节软骨中的归一化造影剂浓度更高。总之，延迟 CT 关节造影显示出用于软骨完整性临床评估的潜力。
We investigated the feasibility of delayed computed tomography (CT) arthrography for evaluation of human knee cartilage in vivo. Especially, the diffusion of contrast agent out of the joint space and the optimal time points for imaging were determined. Two patients were imaged using delayed CT arthrography and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) techniques. Two hours after injection, the concentration of contrast agent in the joint space was still high enough (20% to 24.5% of the initial concentration at 0 minutes) to allow delayed CT arthrography. The half-life of the contrast agent in the joint space varied from 30 to 60 minutes. The contrast agent concentration in patellar and femoral cartilage reached the maximum after 30 and 60 minutes, respectively. According to dGEMRIC, there were no differences between patients. However, in delayed CT arthrography, the penetration of the contrast agent was higher in the osteoarthritic knee cartilage. Contrast agent remained in the joint space long enough to enable delayed CT arthrography of cartilage. After 30 minutes, the normalized contrast agent concentration was higher in the cartilage of the osteoarthritic knee in comparison with the healthy knee. To conclude, delayed CT arthrography exhibited potential for use in the clinical evaluation of cartilage integrity.
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影响因子：
5.9
作者：
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通讯作者：
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