Distinct effects of the basal ganglia and cerebellum on the thalamocortical pathway in idiopathic generalized epilepsy.
Distinct effects of the basal ganglia and cerebellum on the thalamocortical pathway in idiopathic generalized epilepsy.
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基底神经节和小脑对特发性全身性癫痫丘脑皮质通路的独特影响
DOI：
10.1002/hbm.25444
复制
发表时间：
2021-08-01
影响因子：
4.8
通讯作者：
Luo C
中科院分区：
文献类型：
--
作者：
Gong J;Jiang S;Li Z;Pei H;Li Q;Yao D;Luo C
癫痫的异常丘脑皮层通路近年来被发现，但其潜在的影响癫痫仍然没有得到很好的理解。探讨特发性全身性癫痫（IGE）患者两个重要的丘脑皮质通路（即基底神经节-丘脑皮质通路和小脑-丘脑皮质通路）的病理性改变，可以加深我们对该病病理机制的理解。本研究结合弥散和功能磁共振成像对这两条通路进行了重建和研究。这两种途径都显示出与患者感知和认知系统的连接变化。一致的功能连接（FC）的变化，主要是在感知区域，揭示了异常整合的感觉运动和视觉信息的IGE。高阶区域的通路特异性FC改变为IGE中认知障碍和癫痫活动的神经机制提供了神经影像学证据。IGE患者小脑、基底节和丘脑的功能和结构整合异常可导致脑内抑制性和兴奋性失衡。本研究定位了IGE中受影响的BG和小脑的调节皮质区域，建立了神经影像学表现与癫痫症状之间的可能联系，丰富了对BG和小脑对癫痫的调节作用的认识。
The aberrant thalamocortical pathways of epilepsy have been detected recently, while its underlying effects on epilepsy are still not well understood. Exploring pathoglytic changes in two important thalamocortical pathways, that is, the basal ganglia (BG)‐thalamocortical and the cerebellum‐thalamocortical pathways, in people with idiopathic generalized epilepsy (IGE), could deepen our understanding on the pathological mechanism of this disease. These two pathways were reconstructed and investigated in this study by combining diffusion and functional MRI. Both pathways showed connectivity changes with the perception and cognition systems in patients. Consistent functional connectivity (FC) changes were observed mainly in perception regions, revealing the aberrant integration of sensorimotor and visual information in IGE. The pathway‐specific FC alterations in high‐order regions give neuroimaging evidence of the neural mechanisms of cognitive impairment and epileptic activities in IGE. Abnormal functional and structural integration of cerebellum, basal ganglia and thalamus could result in an imbalance of inhibition and excitability in brain systems of IGE. This study located the regulated cortical regions of BG and cerebellum which been affected in IGE, established possible links between the neuroimaging findings and epileptic symptoms, and enriched the understanding of the regulatory effects of BG and cerebellum on epilepsy.
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影响因子：
4.3
作者：
Chen M;Guo D;Wang T;Jing W;Xia Y;Xu P;Luo C;Valdes-Sosa PA;Yao D
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影响因子：
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DOI：
10.1073/pnas.1000496107
发表时间：
2010-05-04
影响因子：
11.1
作者：
Bostan, Andreea C.;Dum, Richard P.;Strick, Peter L.
通讯作者：
Strick, Peter L.