Current oscillations generated by precipitate formation in the mixing zone between two solutions inside a nanopore
Current oscillations generated by precipitate formation in the mixing zone between two solutions inside a nanopore
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纳米孔内两种溶液之间的混合区中沉淀物形成产生的电流振荡
DOI：
10.1088/0953-8984/22/45/454127
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Michael Mayer
中科院分区：
文献类型：
--
作者：
E. Yusko;Yazan N. Billeh;Michael Mayer
与脂质膜中的生物蛋白质孔不同，合成材料中制造的纳米孔可以承受广泛的环境条件，包括有机溶剂的存在。这种能力扩大了合成纳米孔监测有机和水性溶液之间界面处发生的化学反应的潜力。在这项工作中，在硼硅酸盐玻璃或氮化硅中制造的纳米孔将主要有机溶剂连接到水性溶剂，从而在孔内的这些溶液之间产生混合区。这种配置被利用来沉淀具有低水溶性的小有机分子在纳米孔内，并且伴随地，通过随时间推移通过纳米孔的离子电导的降低来监测这种沉淀。因此，该方法提供了诱导和研究纳米沉淀物或纳米颗粒形成的手段。有趣的是，带有轻微电荷的沉淀物从孔中清除，导致孔的电导恢复到其原始值。这个过程重复进行，导致离子电流的稳定振荡。虽然这样的振荡可能是有用的流体逻辑电路，很少有条件能够产生振荡的离子电流已被报道。振荡的频率和振幅可以通过改变沉淀分子的浓度、电解质的pH和施加的偏压来调节。除了产生振荡之外，分离两种不同溶液的纳米孔可用于监测和介导两种溶液之间的混合区中的化学反应。
Unlike biological protein pores in lipid membranes, nanopores fabricated in synthetic materials can withstand a wide range of environmental conditions including the presence of organic solvents. This capability expands the potential of synthetic nanopores to monitor chemical reactions occurring at the interface between solutions of organic and aqueous character. In this work, nanopores fabricated in borosilicate glass or silicon nitride connected a predominantly organic solvent to an aqueous solvent, thereby generating a mixing zone between these solutions inside the pore. This configuration was exploited to precipitate small organic molecules with low aqueous solubility inside the nanopores, and concomitantly, to monitor this precipitation by the decrease of the ionic conductance through the nanopores over time. Hence, this method provides a means to induce and investigate the formation of nanoprecipitates or nanoparticles. Interestingly, precipitates with a slight electric charge were cleared from the pore, causing the conductance of the pore to return to its original value. This process repeated, resulting in stable oscillations of the ionic current. Although such oscillations might be useful in fluidic logic circuits, few conditions capable of generating oscillations in ionic currents have been reported. The frequency and amplitude of oscillations could be tuned by changing the concentration of the precipitating molecule, the pH of the electrolyte, and the applied potential bias. In addition to generating oscillations, nanopores that separate two different solutions may be useful for monitoring and mediating chemical reactions in the mixing zone between two solutions.
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影响因子：
15
作者：
Majd, Sheereen;Yusko, Erik C.;MacBriar, Alexander D.;Yang, Jerry;Mayer, Michael
通讯作者：
Mayer, Michael
使用离子通道形成肽来量化蛋白质-配体相互作用。
影响因子：
15
作者：
Mayer,Michael;Semetey,Vincent;Gitlin,Irina;Yang,Jerry;Whitesides,GeorgeM
通讯作者：
Whitesides,GeorgeM
影响因子：
15
作者：
Holden, Matthew A.;Needham, David;Bayley, Hagan
通讯作者：
Bayley, Hagan
DOI：
10.1073/pnas.97.14.8151
发表时间：
2000-07-05
影响因子：
11.1
作者：
Wulff, H;Miller, MJ;Chandy, KG
通讯作者：
Chandy, KG
影响因子：
4
作者：
Fologea, Daniel;Ledden, Bradley;Li, Jiali
通讯作者：
Li, Jiali