Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease.
Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease.
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DOI：
10.3389/fcell.2021.706997
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发表时间：
2021
影响因子：
5.5
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Wang L;Sun X;He J;Liu Z
泛素化是蛋白质的翻译后修饰，其显著影响蛋白质的稳定性和功能。底物识别的特异性由泛素化过程中的泛素E3连接酶决定。人Deltex（DTX）蛋白家族作为泛素E3连接酶发挥功能，包括5个成员，即DTX1、DTX2、DTX3、DTX3L和DTX4。在过去的十年中，DTX家族蛋白的特征和功能多样性引起了人们的极大关注。DTX蛋白具有多种生理和病理作用，与细胞信号转导、生长、分化和凋亡以及各种肿瘤的发生发展密切相关。虽然他们已经在各种物种中进行了广泛的研究，但关于DTX家族蛋白的结构特征、生物学功能和潜在作用机制的数据仍然有限。本文综述了近年来DTX家族成员的研究进展，并对未来的研究方向和疾病诊断与治疗策略进行了展望。
Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, comprises five members, namely, DTX1, DTX2, DTX3, DTX3L, and DTX4. The characteristics and functional diversity of the DTX family proteins have attracted significant attention over the last decade. DTX proteins have several physiological and pathological roles and are closely associated with cell signal transduction, growth, differentiation, and apoptosis, as well as the occurrence and development of various tumors. Although they have been extensively studied in various species, data on structural features, biological functions, and potential mechanisms of action of the DTX family proteins remain limited. In this review, recent research progress on each member of the DTX family is summarized, providing insights into future research directions and potential strategies in disease diagnosis and therapy.
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影响因子：
14.9
作者：
CORPET, F
通讯作者：
CORPET, F
DOI：
10.1038/nrm.2017.53
发表时间：
2017-10
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Ray Chaudhuri A;Nussenzweig A
通讯作者：
Nussenzweig A
NLRP4 通过泛素连接酶 DTX4 靶向激酶 TBK1 进行降解，从而负调节 I 型干扰素信号传导
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
13.6
作者：
Chatrin C;Gabrielsen M;Buetow L;Nakasone MA;Ahmed SF;Sumpton D;Sibbet GJ;Smith BO;Huang DT
通讯作者：
Huang DT
DOI：
10.1073/pnas.1610432113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Ammeux, Noemie;Housden, Benjamin E.;Perrimon, Norbert
通讯作者：
Perrimon, Norbert