Characteristics of SARS-CoV-2 and COVID-19.

Characteristics of SARS-CoV-2 and COVID-19.
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SARS-CoV-2 和 COVID-19 的特征

DOI:
10.1038/s41579-020-00459-7
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发表时间:
2021-03
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
Shi ZL
Shi ZL
中科院分区:
其他
文献类型:
--
作者:
Hu B;Guo H;Zhou P;Shi ZL

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严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)是一种高度传播和致病的冠状病毒,于2019年底出现,并已引起急性呼吸道疾病大流行,被称为“2019冠状病毒病”(COVID-19),威胁人类健康和公共安全。在这篇综述中,我们描述了SARS-CoV-2的基本病毒学,包括基因组特征和受体使用,突出了它与以前已知的冠状病毒的关键区别。本文综述了COVID-19的临床、流行病学和病理学特征,以及SARS-CoV-2感染的动物模型和抗病毒治疗方法的最新进展。我们还详细讨论了这种新出现的病毒的潜在野生动物宿主和人畜共患起源。在这篇综述中,Shi及其同事总结了自2019年急性呼吸道综合征冠状病毒2(SARS-CoV-2)和冠状病毒病(COVID-19)席卷地球仪以来的大量研究。他们讨论了我们迄今为止所知道的关于SARS-CoV-2的出现和病毒学以及COVID-19的发病机制和治疗。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail. In this Review, Shi and colleagues summarize the exceptional amount of research that has characterized acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) since this virus has swept around the globe. They discuss what we know so far about the emergence and virology of SARS-CoV-2 and the pathogenesis and treatment of COVID-19.
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