Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis.
Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis.
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DOI：
10.1002/art.38273
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发表时间：
2014-03
影响因子：
13.3
通讯作者：
Tak, P. P.
中科院分区：
文献类型：
--
作者：
de Hair, M. J. H.;van de Sande, M. G. H.;Ramwadhdoebe, T. H.;Hansson, M.;Landewe, R.;van der Leij, C.;Maas, M.;Serre, G.;van Schaardenburg, D.;Klareskog, L.;Gerlag, D. M.;van Baarsen, L. G. M.;Tak, P. P.
先前的研究结果表明，滑膜的亚临床炎症与类风湿性关节炎（RA）特异性自身抗体的出现并不相符。这项研究的目的是在一项规模明显更大的前瞻性研究中，探讨自身抗体的存在、滑膜变化和关节炎随时间的发展之间的关系。该研究纳入了 55 名 IgM 类风湿因子阳性和/或抗瓜氨酸蛋白抗体 (ACPA) 阳性（通过抗环瓜氨酸肽抗体测试检测）且体检时没有任何关节炎证据的个体。随后还使用基于多重芯片的测定法检测了 ACPA。所有个体在纳入时均接受了磁共振成像和膝关节微型关节镜滑膜活检取样，并进行了前瞻性随访。进行比例风险回归分析以调查滑膜的变化是否与关节炎的发病相关。 15 名个体 (27%) 在中位随访时间 13 个月后出现关节炎（四分位数范围 6-27 个月；范围 1-47 个月）。没有观察到明显的滑膜炎症，但活检组织中的 CD3+ T 细胞数量显示与随后出现临床症状的关节炎存在一定的相关性（风险比 2.8，95% 置信区间 [95% CI] 0.9–9.1；P = 0.088）。此外，CD8+ T 细胞的存在与 ACPA 阳性（比值比 [OR] 16.0，95% CI 1.7-151.1）以及存在的 ACPA 总数（OR 1.4，95% CI 1.0-1.8）相关。这些发现证实并扩展了先前的结果，表明患有与 RA 相关的全身性自身免疫的个体不存在明显的滑膜炎症。然而，在临床前 RA 中，滑膜 T 细胞的微妙浸润可能先于关节炎的体征和症状。
Findings from previous studies have suggested that subclinical inflammation of the synovium does not coincide with the appearance of rheumatoid arthritis (RA)–specific autoantibodies. This study was undertaken to examine the relationship between the presence of autoantibodies, changes in the synovium, and development of arthritis over time in a markedly larger, prospective study. Fifty-five individuals who were IgM rheumatoid factor positive and/or anti–citrullinated protein antibody (ACPA) positive (detected by the anti–cyclic citrullinated peptide antibody test) and who were without any evidence of arthritis upon physical examination were included in the study. ACPAs were subsequently also detected using a multiplex chip-based assay. All individuals underwent magnetic resonance imaging and mini-arthroscopic synovial biopsy sampling of a knee joint at inclusion and were prospectively followed up. Proportional hazards regression analysis was performed to investigate whether changes in the synovium were associated with the onset of arthritis. Fifteen individuals (27%) developed arthritis after a median followup time of 13 months (interquartile range 6–27 months; range 1–47 months). No overt synovial inflammation was observed, but CD3+ T cell numbers in the biopsy tissue showed a borderline association with subsequent development of clinically manifest arthritis (hazard ratio 2.8, 95% confidence interval [95% CI] 0.9–9.1; P = 0.088). In addition, the presence of CD8+ T cells was associated with ACPA positivity (odds ratio [OR] 16.0, 95% CI 1.7–151.1) and with the total number of ACPAs present (OR 1.4, 95% CI 1.0–1.8). These findings confirm and extend previous results showing the absence of clearcut synovial inflammation in individuals having systemic autoimmunity associated with RA. However, subtle infiltration by synovial T cells may precede the signs and symptoms of arthritis in preclinical RA.
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影响因子：
27.4
作者：
Gerlag DM;Raza K;van Baarsen LG;Brouwer E;Buckley CD;Burmester GR;Gabay C;Catrina AI;Cope AP;Cornelis F;Dahlqvist SR;Emery P;Eyre S;Finckh A;Gay S;Hazes JM;van der Helm-van Mil A;Huizinga TW;Klareskog L;Kvien TK;Lewis C;Machold KP;Rönnelid J;van Schaardenburg D;Schett G;Smolen JS;Thomas S;Worthington J;Tak PP
通讯作者：
Tak PP
简要报告：无关节炎受试者的气道异常和类风湿性关节炎相关自身抗体：早期损伤或自身免疫的起始部位？
影响因子：
--
作者：
Demoruelle, M. Kristen;Weisman, Michael H.;Simonian, Philip L.;Lynch, David A.;Sachs, Peter B.;Pedraza, Isabel F.;Harrington, Annie R.;Kolfenbach, Jason R.;Striebich, Christopher C.;Pham, Quyen N.;Strickland, Colin D.;Petersen, Brian D.;Parish, Mark C.;Derber, Lezlie A.;Norris, Jill M.;Holers, V. Michael;Deane, Kevin D.
通讯作者：
Deane, Kevin D.
DOI：
10.1016/j.berh.2005.01.005
发表时间：
2005-06-01
影响因子：
5.2
作者：
Gerlag, D;Tak, PP
通讯作者：
Tak, PP
影响因子：
--
作者：
Nielen, MMJ;van Schaardenburg, D;Dijkmans, BAC
通讯作者：
Dijkmans, BAC
影响因子：
5.4
作者：
Sebbag, Mireille;Moinard, Nathalie;Serre, Guy
通讯作者：
Serre, Guy