Streptococcus pneumoniae: 'captain of the men of death' and financial burden.
Streptococcus pneumoniae: 'captain of the men of death' and financial burden.
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DOI:
10.1099/mic.0.001275
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发表时间:
2022-12
期刊:
影响因子:
2.8
通讯作者:
Andrew, Peter W.
中科院分区:
文献类型:
--
作者:
Yesilkaya, Hasan;Oggioni, Marco R.;Andrew, Peter W.
Streptococcus pneumoniae may inhabit the upper respiratory tract of humans without causing harm but it also causes diseases with high morbidity and mortality. It has excellent adaptive capabilities thanks to its ability to shuffle its genetic content by acquiring and incorporating DNA from other bacteria and is highly competent for genetic transformation. Sugar sensing, cleavage and transport ensure its fitness and survival in the host, and intracellular survival in macrophages has been linked to virulence. The polysaccharide capsule and toxin pneumolysin are the most important virulence determinants. Polysaccharide-based vaccines provide protection against the serotypes represented in vaccine formulations.
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影响因子:
2.7
作者:
Kapatai G;Sheppard CL;Al-Shahib A;Litt DJ;Underwood AP;Harrison TG;Fry NK
通讯作者:
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3.1
作者:
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Andrew, PW
DOI:
10.1073/pnas.182380799
发表时间:
2002-09-17
影响因子:
11.1
作者:
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28.3
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通讯作者:
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影响因子:
3.9
作者:
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