Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?
Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?
复制标题
内皮祖细胞（EPC）对头颈鳞状细胞癌（HNSCC）肿瘤发生的意义：肿瘤进展和新血管形成的可能标志物？
DOI：
10.1007/s00784-016-1785-4
复制
发表时间：
2016
影响因子：
3.4
通讯作者：
Lambrecht T
中科院分区：
文献类型：
--
作者：
Ziebart T;Blatt S;Günther C;Völxen N;Pabst A;Sagheb K;Kühl S;Lambrecht T
目的血管生成和新生血管在头颈部鳞状细胞癌(HNSCC)的发生、发展中起重要作用。本研究的目的是探讨肿瘤患者内皮祖细胞(EPC)的新生血管能力作为预测肿瘤进展和肿瘤分期的可能指标。从79例不同病期HNSCC患者的外周静脉血中分离出细胞。结果肿瘤患者外周血巨噬细胞的迁移率(1027±11510)显著高于对照组(632±269)，克隆形成单位(CFU)测定的克隆活性(19.7±112.3)明显高于对照组(10.84±44.8)。为了确定EPC数是否可以作为肿瘤患者临床预后的有效指标，我们进一步比较了Kaplan-Meier生存曲线中“高EPC数亚组”(HI)和“低EPC数亚组”(LO)。结论我们的研究结果表明EPC可能在HNSCC的血管生成中发挥关键作用，从而在HNSCC的进展中发挥关键作用。临床相关性。我们的发现可以作为HNSCC肿瘤患者新生血管潜能的可能预测因子。
ObjectivesAngiogenesis and neovascularisation plays a crucial role for tumorigenesis and tumor progression in head and neck squamous cell carcinoma (HNSCC). The aim of our study was to investigate the neovascularization capacity by endothelial progenitor cells (EPC) in tumor patient as a possible predictor for tumor progression and tumor stage.Materials and methodsTherefore, we investigated the cell number and biologic activity by cell migration and colony-forming ability of EPC. Cells were isolated from the peripheral venous blood of 79 patients who suffer HNSCC in different stages of disease. Thirty-three healthy individuals served as the control group.ResultsSignificantly increased biological activities were reflected by expression of the migration rate (1027 ± 1510) in comparison to the control group (632 ± 269) and the clonal potency measured by colony-forming unit (CFU) (tumor patients (19.7 ± 12.3) vs. control group (10.84 ± 4.8)). To determine whether or not EPC number can be used as a valid prognostic marker for clinical outcome of tumor patients, we furthermore compared a “high EPC-number-subgroup” (HI) with a “low EPC-number-subgroup” (LO) in a Kaplan-Meier survival curve. The HI-subgroup shows herein clearly a worse outcome.ConclusionsOur findings indicate a possible pathway for EPC to play a critical role in the vasculogenesis and consequently in the progression of HNSCC.Clinical Relevance.Our findings could serve as possible predictors for the neovascularisation potential in HNSCC tumor patients.
登录
查看更多内容
影响因子：
3.1
作者：
Krueger, M.;Pabst, A. M.;Ziebart, T.
通讯作者：
Ziebart, T.
内皮集落形成单位：它们是内皮祖细胞数量的可靠标志吗？
DOI：
--
发表时间：
2007
期刊：
Annals medicus
影响因子：
--
作者：
E. Shantsila;T. Watson;Hung Fat Tse;G. Lip
通讯作者：
G. Lip
研究不同双磷酸盐对癌症治疗中 EPC 介导的新血管形成的抑制作用。
影响因子：
2.3
作者：
T. Ziebart;Johanna Ziebart;Leonie Gauss;A. Pabst;M. Ackermann;R. Smeets;M. Konerding;C. Walter
通讯作者：
C. Walter
类异戊二烯香叶基香叶醇：体外双膦酸盐治疗后对内皮祖细胞细胞特性的影响
影响因子：
3.4
作者：
A. Pabst;Maximilian Krüger;T. Ziebart;C. Jacobs;Christian Walter
通讯作者：
Christian Walter
肿瘤模型中内皮生长细胞的体内生物分布和归巢。
影响因子：
3.1
作者：
L. Bertelsen;M. Hagensen;M. Busk;Rui Zhang;A. S. Knudsen;N. Nielsen;L. Falborg;B. Møller;M. Horsman;H. Stødkilde
通讯作者：
H. Stødkilde