The microbiota-gut-brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models.
The microbiota-gut-brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models.
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DOI：
10.1002/btm2.10296
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发表时间：
2022-05
影响因子：
7.4
通讯作者：
Striano, Pasquale
中科院分区：
文献类型：
--
作者：
Fusco, Federica;Perottoni, Simone;Giordano, Carmen;Riva, Antonella;Iannone, Luigi Francesco;De Caro, Carmen;Russo, Emilio;Albani, Diego;Striano, Pasquale
癫痫是一种常见的神经系统疾病，其特征在于大脑产生癫痫发作的持久倾向。在公认的原因中，肠道微生物群在癫痫中发挥的作用已经被假设并得到新的研究方法的支持。为了剖析癫痫中涉及的微生物群-肠-脑（MGB）轴，体外建模方法引起了该领域研究人员的兴趣。本文首先总结了MGB轴在癫痫中的作用的证据，概述了最近的临床和临床前研究，并显示了饮食调整，微生物组表达，因此，微生物群改变可能对癫痫发作产生影响。随后，目前可用的策略来研究癫痫的动物和体外模型进行了描述，集中注意力在这些后者和技术的挑战与现有的MGB轴模型集成。最后，现有的癫痫体外系统的实施进行了讨论，提供了一个完整的概述，可用的技术工具，可以提高可靠性和临床翻译的结果对创新的治疗方法的发展，利用互补技术。
Epilepsy is a common neurological disease characterized by the enduring predisposition of the brain to generate seizures. Among the recognized causes, a role played by the gut microbiota in epilepsy has been hypothesized and supported by new investigative approaches. To dissect the microbiota‐gut‐brain (MGB) axis involvement in epilepsy, in vitro modeling approaches arouse interest among researchers in the field. This review summarizes, first of all, the evidence of a role of the MGB axis in epilepsy by providing an overview of the recent clinical and preclinical studies and showing how dietary modification, microbiome supplementations, and hence, microbiota alterations may have an impact on seizures. Subsequently, the currently available strategies to study epilepsy on animal and in vitro models are described, focusing attention on these latter and the technological challenges for integration with already existing MGB axis models. Finally, the implementation of existing epilepsy in vitro systems is discussed, offering a complete overview of the available technological tools which may improve reliability and clinical translation of the results towards the development of innovative therapeutic approaches, taking advantage of complementary technologies.
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影响因子：
23.9
作者：
Bershteyn M;Nowakowski TJ;Pollen AA;Di Lullo E;Nene A;Wynshaw-Boris A;Kriegstein AR
通讯作者：
Kriegstein AR
影响因子：
6.1
作者：
Chen HJ;Miller P;Shuler ML
通讯作者：
Shuler ML
影响因子：
2.9
作者：
Akimitsu, T;Kurisu, K;Sasa, M
通讯作者：
Sasa, M
影响因子：
3.4
作者：
BRENER, K;AMITAI, Y;GUTNICK, MJ
通讯作者：
GUTNICK, MJ
影响因子：
3
作者：
Boehler, Michael D.;Leondopulos, Stathis S.;Wheeler, Bruce C.;Brewer, Gregory J.
通讯作者：
Brewer, Gregory J.