A major difference between the divergence patterns within the lines-1 families in mice and voles.
A major difference between the divergence patterns within the lines-1 families in mice and voles.
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小鼠和田鼠的lines-1家族内的分歧模式之间的主要区别。
DOI：
10.1093/oxfordjournals.molbev.a040040
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发表时间：
1993
影响因子：
10.7
通讯作者：
Edgell,MH
中科院分区：
文献类型：
--
作者：
Vanlerberghe,F;Bonhomme,F;Hutchison3rd,CA;Edgell,MH
L1逆转录子在小鼠中由不同丰度的分散序列亚家族代表。先前的分析表明，亚科是由L1家族的少数成员的重复转位产生的，这些成员的后代随后成为小鼠L1群体的主要组成部分，而不是由于特定物种中预先存在的元素群中产生同源性的任何活跃过程。在小鼠中，超过三分之一的L1元素属于一个大约在5000万年前开始活跃的分支，其元素相同度为50%或95%。我们收集了2种田鼠（rodena: Microtinae: Microtus和Arvicola）的13个L1元件的序列信息，发现田鼠L1群体的分化与小鼠的差异很大，没有丰富的同源元件亚家族。田鼠的单个L1元素彼此之间差异很大，属于一个大约在13亿年前开始高度重复转位的分支。对这些不同L1元件的部分序列分析（每个约250 bp）没有发现自3.5亿年前两个田鼠谱系分裂以来协同进化作用于田鼠L1元件的证据；即观察到的种间差异（6.7% ~ 24.7%）不大于种内差异（7.9% ~ 27.2%），系统发育分析没有显示出Arvicola和Microtus分支的聚类。
L1 retroposons are represented in mice by subfamilies of interspersed sequences of varied abundance. Previous analyses have indicated that subfamilies are generated by duplicative transposition of a small number of members of the L1 family, the progeny of which then become a major component of the murine L1 population, and are not due to any active processes generating homology within preexisting groups of elements in a particular species. In mice, more than a third of the L1 elements belong to a clade that became active approximately 5 Mya and whose elements are > or = 95% identical. We have collected sequence information from 13 L1 elements isolated from two species of voles (Rodentia: Microtinae: Microtus and Arvicola) and have found that divergence within the vole L1 population is quite different from that in mice, in that there is no abundant subfamily of homologous elements. Individual L1 elements from voles are very divergent from one another and belong to a clade that began a period of elevated duplicative transposition approximately 13 Mya. Sequence analyses of portions of these divergent L1 elements (approximately 250 bp each) gave no evidence for concerted evolution having acted on the vole L1 elements since the split of the two vole lineages approximately 3.5 Mya; that is, the observed interspecific divergence (6.7%-24.7%) is not larger than the intraspecific divergence (7.9%-27.2%), and phylogenetic analyses showed no clustering into Arvicola and Microtus clades.
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影响因子：
5.3
作者：
Bruce E. Kimmel;K. Onesmo;OLE-MOIYOI;John R. Young
通讯作者：
Bruce E. Kimmel;K. Onesmo;OLE-MOIYOI;John R. Young
小鼠 F9 细胞中链特异性 LINE-1 转录源自 LINE-1 元件最年轻的系统发育亚组。
影响因子：
5.6
作者：
Schichman,SA;Severynse,DM;Edgell,MH;Hutchison3rd,CA
通讯作者：
Hutchison3rd,CA
使用便携式计算机进行测序凝胶读数。
影响因子：
14.9
作者：
Hutchison3rd,CA
通讯作者：
Hutchison3rd,CA
小鼠 LINE-1 重复元件 5 端的不相关序列定义了两个不同的亚家族。
影响因子：
14.9
作者：
P. Wincker;V. Jubier;G. Roizes
通讯作者：
G. Roizes
影响因子：
5.6
作者：
V. Jubier;B. Dod;M. Bellis;M. Piechaczyk;G. Roizes
通讯作者：
G. Roizes