Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients.
Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients.
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MTHFR C677T多态性与精神分裂症的关联及其对患者情景记忆和灰质密度的影响
DOI：
10.1016/j.bbr.2012.12.061
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发表时间：
2013-04-15
影响因子：
2.7
通讯作者：
Yue, Weihua
中科院分区：
文献类型：
--
作者：
Zhang, Yanling;Yan, Hao;Tian, Lin;Wang, Fang;Lu, Tianlan;Wang, Lifang;Yan, Jun;Liu, Qi;Kang, Lan;Ruan, Yanyan;Zhang, Dai;Yue, Weihua
关键词：
越来越多的证据表明，亚甲基四氢叶酸还原酶（MTHFR）可能在精神分裂症的发病机制中发挥作用。最近的研究表明，MTHFR 677 T作为一个危险等位基因，对精神分裂症患者的脑激活和记忆功能有影响。为进一步证实MTHFR C677 T基因多态性与精神分裂症的相关性，我们采用直接DNA测序法检测了1,002例精神分裂症患者和1,036例正常对照的MTHFR C677 T基因多态性。为进一步探讨MTHFR C677 T基因多态性对精神分裂症患者记忆和脑功能的影响，从上述样本中选取33例精神分裂症患者和29例健康对照者，进行MRI扫描和情景记忆（episodic memory，EM）检查。病例对照关联研究结果显示MTHFR C677 T与精神分裂症相关（χ2 = 14.11，P = 1.74 × 10−4，OR = 0.79; 95%CI = 0.70 ~ 0.89）。我们还发现MTHFR 677 T等位基因对精神分裂症患者的EM有负荷依赖性影响，但在健康对照组中没有。进一步分析灰质密度（GMD）显示，MTHFR基因型在双侧额叶皮质、双侧颞叶皮质、左侧内侧颞叶皮质和双侧枕叶皮质具有显著的诊断效应，在右侧额叶皮质、右侧额下回、右侧罗兰岛盖、右侧海马旁回和右侧内侧颞极具有显著的诊断效应，在右侧颞回具有显著的基因型-诊断交互效应。提示MTHFR 677 T等位基因可能与精神分裂症的发病风险、记忆障碍和GMD改变有关。
Growing evidence suggests that the methylenetetrahydrofolate reductase (MTHFR) may play a role in the pathogenesis of schizophrenia. Recent studies suggested that the MTHFR 677T, as a risk allele, has an impact on brain activation and memory function in schizophrenia patients. To confirm further the association between this functional polymorphism and schizophrenia, we detected genotypes of MTHFR C677T polymorphism in 1,002 schizophrenic patients and 1,036 controls of Chinese Han population, by using direct DNA sequencing method. To explore further effects of MTHFR C677T polymorphism on memory and brain function in schizophrenia, 33 schizophrenia patients and 29 healthy participants were selected from above samples to be assessed with MRI scanning and episodic memory (EM) examination. The case - control association study results showed that the MTHFR C677T was associated with schizophrenia (χ2 = 14.11, P = 1.74 × 10−4, OR = 0.79; 95% CI = 0.70 – 0.89). We also found that the MTHFR 677T allele had a load-dependent effect on EM in schizophrenic patients, but not in healthy control participants. Further analysis on gray matter density (GMD) revealed significant diagnostic effects in bilateral frontal cortices, bilateral insula, left medial temporal cortex and bilateral occipital cortices, effects of MTHFR genotype in the right insula, right inferior frontal gyrus, right rolandic opercula, right parahippocampal gyrus and right medial temporal pole, and effects of genotype-diagnosis interaction in the right temporal gyrus. Our findings suggested that the MTHFR 677T allele might have effect on risk of schizophrenia, memory impairment and GMD changes in patients.
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影响因子：
5.7
作者：
Hayasaka, S;Phan, KL;Nichols, TE
通讯作者：
Nichols, TE
影响因子：
6.9
作者：
Kendler, KS;Gardner, CO
通讯作者：
Gardner, CO
DOI：
10.1002/ajmg.b.30179
发表时间：
2005-05-05
影响因子：
2.8
作者：
Muntjewerff, JW;Hoogendoorn, MLC;Blom, HJ
通讯作者：
Blom, HJ
影响因子：
--
作者：
Cannon, TD;Kaprio, J;Koskenvuo, M
通讯作者：
Koskenvuo, M
影响因子：
30.8
作者：
Allen, Nicole C.;Bagade, Sachin;Bertram, Lars
通讯作者：
Bertram, Lars