Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism.
Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism.
复制标题
2至4岁自闭症儿童杏仁核体积和联合注意力的纵向研究。
DOI：
10.1001/archgenpsychiatry.2009.19
复制
发表时间：
2009-05
影响因子：
--
通讯作者：
Piven, Joseph
中科院分区：
文献类型：
--
作者：
Mosconi, Matthew W.;Cody-Hazlett, Heather;Poe, Michele D.;Gerig, Guido;Gimpel-Smith, Rachel;Piven, Joseph
据报道，2至4岁自闭症儿童的大脑皮质体积增大。在这一发展时期，人们对分区域的数量知之甚少。杏仁核被假设为体积异常，并与自闭症的核心临床特征有关。研究孤独症儿童2岁时的杏仁核体积，并在4岁时进行随访，探讨杏仁核体积与孤独症特定行为特征之间的关系。纵向磁共振成像研究。大学医疗环境。年龄在18至35个月（2岁）之间的52名自闭症儿童和33名对照儿童（11名发育迟缓，22名正常发育）在42至59个月（4岁）时随访。杏仁核体积与联合注意力能力的测量与一个新的观察编码系统，社会定向连续体和反应量表;组比较，包括总组织体积，性别，智商和年龄作为协变量。杏仁核扩大观察对象与自闭症在2和4岁。观察到体积随时间发生显著变化，但变化率在组间无差异。杏仁核体积与4岁自闭症患者的联合注意力能力相关。在2岁时，自闭症患者的杏仁核相对于对照组增大，但在2岁至4岁之间，杏仁核的大小没有相对增加。杏仁核体积和联合注意力之间的显着关联表明，这种结构的改变可能与自闭症的核心缺陷有关。
Cerebral cortical volume enlargement has been reported in 2- to 4-year-olds with autism. Little is known about the volume of sub-regions during this period of development. The amygdala is hypothesized to be abnormal in volume and related to core clinical features in autism. To examine amygdala volume at 2 years with follow-up at 4 years of age in children with autism and to explore the relationship between amygdala volume and selected behavioral features of autism. Longitudinal magnetic resonance imaging study. University medical setting. Fifty-two autistic and 33 control (11 developmentally delayed, 22 typically developing) children between 18 and 35 months (2 years) of age followed up at 42 to 59 months (4 years) of age. Amygdala volumes in relation to joint attention ability measured with a new observational coding system, the Social Orienting Continuum and Response scale; group comparisons including total tissue volume, sex, IQ and age as covariates. Amygdala enlargement was observed in subjects with autism at both 2 and 4 years of age. Significant change over time in volume was observed, though the rate of change did not differ between groups. Amygdala volume was associated with joint attention ability at age 4 years in subjects with autism. The amygdala is enlarged in autism relative to controls by age 2 years but shows no relative increase in magnitude between 2 and 4 years of age. A significant association between amygdala volume and joint attention suggests that alterations to this structure may be linked to a core deficit of autism.
登录
查看更多内容
影响因子：
16.2
作者：
Breiter, HC;Etcoff, NL;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
14.5
作者：
Bailey, A;Luthert, P;Lantos, P
通讯作者：
Lantos, P
影响因子：
4.8
作者：
Hadjikhani, Nouchine;Joseph, Robert M.;Tager-Flusberg, Helen
通讯作者：
Tager-Flusberg, Helen
DOI：
10.1111/j.2044-835x.1989.tb00793.x
发表时间：
1989-06-01
影响因子：
2.3
作者：
BARONCOHEN, S
通讯作者：
BARONCOHEN, S
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M