Action boosts episodic memory encoding in humans via engagement of a noradrenergic system
Action boosts episodic memory encoding in humans via engagement of a noradrenergic system
复制标题
行动通过去甲肾上腺素能系统的参与增强人类的情景记忆编码
作者：
M. Yebra;Ana Galarza;V. Soto;J. González;Archy O. de Berker;S. Bestmann;A. Oliviero;Marijn C. W. Kroes;B. Strange
当我们编码记忆时，我们不断地与环境互动。然而，行为如何影响记忆的形成仍然知之甚少。目标导向运动涉及蓝斑（LC），这是大脑中去甲肾上腺素的主要来源。去甲肾上腺素也被认为可以增强情景编码，这表明行动可以通过LC参与来改善记忆。在这里，我们证明，在七个实验中，行动（去反应）增强情节编码无关的刺激的行动本身，相比行动抑制（NoGo）。功能性磁共振成像和瞳孔直径作为LC-去甲肾上腺素传递的代理指标，表明在作用过程中编码相关LC活性增加。最后一个实验，在两个独立的样本中重复，证实了一个新的预测来自这些数据，情绪厌恶的刺激，招募去甲肾上腺素能系统，调节记忆优势所赋予的去反应相对于中性刺激。因此，我们提供了一致的证据表明，行动通过去甲肾上腺素能机制增强情景记忆编码。目标导向的运动可以促进大脑中去甲肾上腺素的释放，去甲肾上腺素可以增强记忆编码。在这里，作者提供的证据表明，与动作抑制相比，主动运动通过去甲肾上腺素能机制增强了人类的情景记忆编码。
We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline in the brain. Noradrenaline is also known to enhance episodic encoding, suggesting that action could improve memory via LC engagement. Here we demonstrate, across seven experiments, that action (Go-response) enhances episodic encoding for stimuli unrelated to the action itself, compared to action inhibition (NoGo). Functional magnetic resonance imaging, and pupil diameter as a proxy measure for LC-noradrenaline transmission, indicate increased encoding-related LC activity during action. A final experiment, replicated in two independent samples, confirmed a novel prediction derived from these data that emotionally aversive stimuli, which recruit the noradrenergic system, modulate the mnemonic advantage conferred by Go-responses relative to neutral stimuli. We therefore provide converging evidence that action boosts episodic memory encoding via a noradrenergic mechanism. Goal-directed movement is known to promote release of noradrenaline in the brain, and noradrenaline is known to enhance memory encoding. Here, the authors provide evidence that active movement, compared to action inhibition, boosts episodic memory encoding in humans via a noradrenergic mechanism.
影响因子：
56.9
作者：
Brewer, JB;Zhao, Z;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
1.8
作者：
Naber, Marnix;Fraessle, Stefan;Einhaeuser, Wolfgang
通讯作者：
Einhaeuser, Wolfgang