From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".
From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".
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DOI：
10.1007/s00395-016-0586-x
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发表时间：
2016-11
影响因子：
9.5
通讯作者：
Preissner KT
中科院分区：
文献类型：
--
作者：
Cabrera-Fuentes HA;Aragones J;Bernhagen J;Boening A;Boisvert WA;Bøtker HE;Bulluck H;Cook S;Di Lisa F;Engel FB;Engelmann B;Ferrazzi F;Ferdinandy P;Fong A;Fleming I;Gnaiger E;Hernández-Reséndiz S;Kalkhoran SB;Kim MH;Lecour S;Liehn EA;Marber MS;Mayr M;Miura T;Ong SB;Peter K;Sedding D;Singh MK;Suleiman MS;Schnittler HJ;Schulz R;Shim W;Tello D;Vogel CW;Walker M;Li QO;Yellon DM;Hausenloy DJ;Preissner KT
在这次会议报告中，特别是解决保护心血管系统免受缺血/再灌注损伤的主题，重点介绍了与心脏调节策略有关的分子机制和患者队列的结果，合并症和药物的影响，以及先天免疫反应在心脏保护中的作用。此外，发育或系统生物学方法在系统地揭示缺血再灌注损伤或心脏再生中涉及的意外成分方面具有巨大潜力。基于心血管疾病中特定血小板整合素、线粒体氧化还原连接蛋白或脂质-二醇化合物的表征，新开发的治疗诊断学和技术的靶向为心肌梗死的诊断和治疗开辟了新的途径，以改善患者的结局。
In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients’ cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia–reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients’ outcome.
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影响因子：
9.5
作者：
Cabrera-Fuentes HA;Alba-Alba C;Aragones J;Bernhagen J;Boisvert WA;Bøtker HE;Cesarman-Maus G;Fleming I;Garcia-Dorado D;Lecour S;Liehn E;Marber MS;Marina N;Mayr M;Perez-Mendez O;Miura T;Ruiz-Meana M;Salinas-Estefanon EM;Ong SB;Schnittler HJ;Sanchez-Vega JT;Sumoza-Toledo A;Vogel CW;Yarullina D;Yellon DM;Preissner KT;Hausenloy DJ
通讯作者：
Hausenloy DJ
DOI：
10.1126/science.1199010
发表时间：
2011-04-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Heallen T;Zhang M;Wang J;Bonilla-Claudio M;Klysik E;Johnson RL;Martin JF
通讯作者：
Martin JF
影响因子：
9.5
作者：
Bell RM;Bøtker HE;Carr RD;Davidson SM;Downey JM;Dutka DP;Heusch G;Ibanez B;Macallister R;Stoppe C;Ovize M;Redington A;Walker JM;Yellon DM
通讯作者：
Yellon DM
影响因子：
10.8
作者：
Boengler, K;Dodoni, G;Schulz, R
通讯作者：
Schulz, R
miR-92a的抑制作用可改善重新内皮化，并防止血管损伤后新内膜形成。
影响因子：
10.8
作者：
Daniel JM;Penzkofer D;Teske R;Dutzmann J;Koch A;Bielenberg W;Bonauer A;Boon RA;Fischer A;Bauersachs J;van Rooij E;Dimmeler S;Sedding DG
通讯作者：
Sedding DG