Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses.
Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses.
复制标题
DOI：
10.3390/v8120321
复制
发表时间：
2016-11-26
期刊：
影响因子：
--
通讯作者：
Oshitani H
中科院分区：
文献类型：
--
作者：
Furuse Y;Matsuzaki Y;Nishimura H;Oshitani H
感染丙型流感病毒引起呼吸道症状很常见，特别是在儿童中。由于很少进行病毒的分离和检测，与甲型和B型流感病毒相比，该病毒的可用序列数量少，难以分析其进化动力学。最近，我们报道了102株病毒的全基因组序列。在这里，我们利用这些数据来阐明该病毒与甲型和B型流感病毒相比的进化特征和传播动力学。沿着我们的数据，我们获得了该病毒血凝素-酯酶基因的公开序列数据;该数据集由1947年至2014年间从14个国家收集的218个病毒独特序列组成。信息学分析显示：（1）多个谱系在全球范围内传播;（2）存在弱且罕见的选择瓶颈;（3）由于弱的正选择和低的诱导突变能力，进化速率较低;（4）尽管诱导了一些影响其抗原性的突变，但没有显著的正选择。丙型流感病毒独特的进化动力学必须由多种因素塑造，包括病毒学，免疫学和流行病学特征。
Infections with the influenza C virus causing respiratory symptoms are common, particularly among children. Since isolation and detection of the virus are rarely performed, compared with influenza A and B viruses, the small number of available sequences of the virus makes it difficult to analyze its evolutionary dynamics. Recently, we reported the full genome sequence of 102 strains of the virus. Here, we exploited the data to elucidate the evolutionary characteristics and phylodynamics of the virus compared with influenza A and B viruses. Along with our data, we obtained public sequence data of the hemagglutinin-esterase gene of the virus; the dataset consists of 218 unique sequences of the virus collected from 14 countries between 1947 and 2014. Informatics analyses revealed that (1) multiple lineages have been circulating globally; (2) there have been weak and infrequent selective bottlenecks; (3) the evolutionary rate is low because of weak positive selection and a low capability to induce mutations; and (4) there is no significant positive selection although a few mutations affecting its antigenicity have been induced. The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics.
登录
查看更多内容
影响因子：
3.7
作者：
Furuse, Yuki;Shimabukuro, Kozue;Oshitani, Hitoshi
通讯作者：
Oshitani, Hitoshi
影响因子：
4.8
作者：
Furuse Y;Suzuki A;Kamigaki T;Oshitani H
通讯作者：
Oshitani H
影响因子：
5
作者：
Kimura, H;Abiko, C;Nakamura, K
通讯作者：
Nakamura, K
DOI：
10.1017/s0022172400021860
发表时间：
1971-01-01
期刊：
JOURNAL OF HYGIENE-CAMBRIDGE
影响因子：
--
作者：
BARCLAY, GR;LEADERWI.LK;FLEWETT, TH
通讯作者：
FLEWETT, TH
影响因子：
2.6
作者：
HOMMA, M;OHYAMA, S;KATAGIRI, S
通讯作者：
KATAGIRI, S