Impaired myogenic responsiveness of renal microvessels in Dahl salt-sensitive rats.
Impaired myogenic responsiveness of renal microvessels in Dahl salt-sensitive rats.
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达尔盐敏感大鼠肾微血管的肌源反应性受损。
DOI：
10.1161/01.res.71.2.471
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发表时间：
1992
影响因子：
20.1
通讯作者：
Murray Epstein
中科院分区：
文献类型：
--
作者：
Tsuneo Takenaka;Hayley G. Forster;Anna De Micheli;Murray Epstein
Dahl 盐敏感 (DS) 大鼠中介导异常肾脏自动调节的机制尚未完全明确。在本研究中，我们评估了离体灌注肾积水 Dahl 大鼠肾脏中小叶间动脉 (ILAs)、传入小动脉 (AAs) 和传出小动脉的肌源反应性。 Dahl 大鼠根据品系（Dahl 耐盐 [DR] 或 DS 大鼠）和饮食钠控制（喂低盐或高盐饮食的大鼠）分为四组。仅在喂食高盐饮食的 DS 大鼠中收缩压升高（202 +/- 4 mm Hg，p 小于 0.05）。通过逐步升高肾动脉压获得肌源性反应。通过计算机辅助视频显微镜测定血管直径。 DS 和 DR 大鼠的肾小球前微血管对肾动脉压变化的反应不同。与 DR 大鼠相比，DS 大鼠对肾动脉压升高的 AA 和 ILA 表现出肌源性反应减弱（p 小于 0.05）。 DS 大鼠中的 AA 和 ILA 均表现出较高的引发肌源性反应的阈值压力和最大压力诱导的血管收缩的降低。与 DR 大鼠相比，DS 大鼠的 AA 肌源性反应对硝苯地平的敏感性增强（p 小于 0.05）。对于喂食高盐饮食的大鼠，两种品系的肾小球前血管均表现出肌源性反应性降低。与肾小球前微血管相反，所有四组大鼠的传出小动脉均未表现出压力诱导的血管收缩。我们的数据表明，DS 大鼠中 AA 和 ILA 的肌源反应性减弱导致该品系的肾脏自动调节受损。
The mechanisms mediating abnormal renal autoregulation in Dahl salt-sensitive (DS) rats have not been fully defined. In the present study, we assessed myogenic responsiveness of interlobular arteries (ILAs), afferent arterioles (AAs), and efferent arterioles in isolated perfused hydronephrotic Dahl rat kidneys. Dahl rats were divided into four groups according to strain (Dahl salt-resistant [DR] or DS rats) and dietary sodium manipulation (rats fed low or high salt diets). Systolic blood pressure was elevated only in DS rats fed the high salt diet (202 +/- 4 mm Hg, p less than 0.05). Myogenic responses were obtained by stepwise elevation of renal arterial pressure. Vessel diameters were determined by computer-assisted videomicroscopy. Preglomerular microvessels of DS and DR rats responded differently to changes in renal arterial pressure. AAs and ILAs manifested diminished myogenic responsiveness to increasing renal arterial pressure in DS rats compared with DR rats (p less than 0.05). Both AAs and ILAs in DS rats manifested a higher threshold pressure for eliciting myogenic responses and a decrease in maximal pressure-induced vasoconstriction. The sensitivity of the AA myogenic response to nifedipine was enhanced in DS rats compared with DR rats (p less than 0.05). For rats fed the high salt diet, preglomerular vessels exhibited reduced myogenic responsiveness in both strains. In contrast to preglomerular microvessels, efferent arterioles from all four groups of rats failed to exhibit pressure-induced vasoconstriction. Our data suggest that diminished myogenic responsiveness of AAs and ILAs in DS rats contributes to impaired renal autoregulation in this strain.
DOI：
10.1152/ajprenal.1986.251.1.f57
发表时间：
1986-07
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Roman
通讯作者：
R. Roman
达尔株遗传性高血压中动脉肌膜特性未改变。
DOI：
10.1152/ajpheart.1981.241.2.h224
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Abel,PW;Trapani,A;Matsuki,N;Ingram,MJ;Ingram,FD;Hermsmeyer,K
通讯作者：
Hermsmeyer,K