Anorectal volume-pressure relations, contraction work, and flow during defecation.
Anorectal volume-pressure relations, contraction work, and flow during defecation.
复制标题
排便期间的厌食直肠体积压力关系，收缩工作和流动。
DOI：
10.1007/s10237-022-01610-4
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发表时间：
2022-10
影响因子：
3.5
通讯作者：
Kassab, Ghassan S.
中科院分区：
文献类型：
--
作者：
Gregersen, Hans;Wang, Yanmin;Field, Fred;Wang, Mengjun;Lo, Kar Man;Guo, Xiaomei;Combs, William;Kassab, Ghassan S.
Fecobionics是一种集成设备，已显示出对肛门直肠功能评估的承诺。我们使用无线Fecobionics原型来可视化排便模式，并计算体积压力，收缩功和流量。研究了12名正常受试者。探针为10 cm长，包含压力传感器和用于阻抗面积测量的电极。分析排便过程中的压力、直径和体积数据。将袋在直肠内扩张至排便水平，然后要求受试者排空。收缩功和排便流量由排出过程中的体积变化计算。排空时最小肛门直径为17.6±1.5mm。中间直径记录比前直径通道低10-20%，比后通道大10-20%。最小直径与最大袋容积呈显著正相关（r=0.63）。直径-压力环和容积-压力环均为逆时针方向，分别对应于充盈期、等长收缩期、射血期和肛门排出期。排便收缩功为3,520± 480 mL·cmH 2 O。排便时最大流量为302± 33 mL/s。流量与肛门直径相关（r=0.84），但与直肠肛门压力梯度无关（r=0.14）。容量-压力环对心肺病理生理学的理解有巨大的影响。未来的研究将阐明排便病理生理学的潜在临床影响。
Fecobionics is an integrated device that has shown promise for assessment of anorectal function. We used a wireless Fecobionics prototype to visualize defecatory patterns and to compute volume-pressure, contraction work, and flow. Twelve normal subjects were studied. The probe was 10-cm-long and contained pressure sensors and electrodes for impedance planimetry. Pressures, diameters, and volume data during defecation were analyzed. The bag was distended inside rectum to the urge-to-defecate level where after the subjects were asked to evacuate. The contraction work and defecatory flow were computed from the volume changes during expulsion. The minimum anal diameter during the evacuation was 17.6±1.5mm. The middle diameter recording was 10–20% lower than the front diameter channels and 10–20% bigger than in the rear channels. The bag volume at urge correlated with the minimum diameter (r=0.63). The diameter-pressure and volume-pressure loops were counterclockwise with phases of bag filling, isometric contraction, ejection and anal passage. The defecatory contraction work was 3,520±480mL*cmH2O. The maximum flow during defecation was 302±33mL/s. The flow was associated to the anal diameter (r=0.84) but not to the rectoanal pressure gradient (r=0.14). Volume-pressure loops have a tremendous impact on the understanding of cardiopulmonary pathophysiology. Future studies will shed light on potential clinical impact in defecatory pathophysiology.
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影响因子：
2.8
作者：
Broens PMA;Jonker JE;Trzpis M
通讯作者：
Trzpis M
影响因子：
2.4
作者：
GIBBONS, CP;BANNISTER, JJ;READ, NW
通讯作者：
READ, NW
影响因子：
9.8
作者：
Noelting, Jessica;Ratuapli, Shiva K.;Zinsmeister, Alan R.
通讯作者：
Zinsmeister, Alan R.
影响因子：
3.2
作者：
Kassab, G. S.;Gregersen, H.;Huang, Z.
通讯作者：
Huang, Z.
DOI：
10.3390/bioengineering7040146
发表时间：
2020-11-14
期刊：
Bioengineering (Basel, Switzerland)
影响因子：
--
作者：
Gregersen H
通讯作者：
Gregersen H