Novel Bionics Assessment of Anorectal Mechanosensory Physiology.
Novel Bionics Assessment of Anorectal Mechanosensory Physiology.
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DOI：
10.3390/bioengineering7040146
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发表时间：
2020-11-14
期刊：
影响因子：
--
通讯作者：
Gregersen H
中科院分区：
文献类型：
--
作者：
Gregersen H
生物机电一体化（仿生学）是一门在生物学和工程学之间建立跨学科联系的应用科学。下胃肠道（GI）很难研究，但近几十年来，从仿生学的角度来看，它已经引起了人们的兴趣。已经开发了记录GI运输期间生理变量的可摄取胶囊，并用于结肠运输和运动的详细分析。最近，开发了一种名为Fecobionics的模拟粪便。它具有正常粪便的稠度和形状。Fecobionics记录了各种参数，包括压力，弯曲和形状变化。它已被用于研究大型动物和人类的排便模式，包括有排便障碍和大便失禁症状的患者。最近，它被应用于犬结肠模型，其中它揭示了与源于卡哈尔间质细胞产生的慢波的浅波一致的模式。新的分析，如“后前”压力图和定量排便指数已开发的Fecobionics。GI研究传统上是基于实验方法。数学建模是处理复杂性的一种独特方法。本文介绍了Fecobionics技术，相关的机械生理建模分析，并概述了未来的应用前景。
Biomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view. Ingestible capsules that record physiological variables during GI transit have been developed and used for detailed analysis of colon transit and motility. Recently, a simulated stool named Fecobionics was developed. It has the consistency and shape of normal stool. Fecobionics records a variety of parameters including pressures, bending, and shape changes. It has been used to study defecation patterns in large animals and humans, including patients with symptoms of obstructed defecation and fecal incontinence. Recently, it was applied in a canine colon model where it revealed patterns consistent with shallow waves originating from slow waves generated by the interstitial Cells of Cajal. Novel analysis such as the “rear-front” pressure diagram and quantification of defecation indices has been developed for Fecobionics. GI research has traditionally been based on experimental approaches. Mathematical modeling is a unique way to deal with the complexity. This paper describes the Fecobionics technology, related mechano-physiological modeling analyses, and outlines perspectives for future applications.
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