P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.
P-selectin: an unpredicted factor for deep vein thrombosis after total hip arthroplasty.
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DOI：
10.1155/2014/783967
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发表时间：
2014
影响因子：
--
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Shi D;Xu X;Xu Z;Nakamura T;Pang Y;Yao C;Wang F;Chen D;Dai J;Jiang Q
导论.深静脉血栓形成（DVT）是全髋关节置换术（THA）后的严重并发症。它会导致急性肺栓塞，一种危及生命的疾病。P-选择素是一种140 kDa的跨膜糖蛋白。P-选择素升高与静脉血栓形成风险增加1.7倍相关。材料与方法。为了证实这种关联，研究了由一名熟练的骨科医生采用外侧入路进行初次全髋关节置换术的91名受试者。所有患者均于2010年至2012年在南京大学医学院附属鼓楼医院关节病诊疗中心连续入组。术后3-5天行静脉造影。我们测量P-选择素通过一个高度敏感的夹心ELISA技术和市售的测试试剂集。结果P-选择素与下肢深静脉血栓形成无明显相关性（P均> 0.05）。Δ sP-选择素与体重、术后APTT、DVT史、原发病诊断相关（P值分别为0.03、0.03、0.04、0.02）。结论P-选择素可能不是全髋关节置换术后深静脉血栓形成的预测因子。
Introduction. Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. Materials and Methods. To confirm the association, a total of 91 subjects who received primary total hip arthroplasty using lateral approach performed by one skilled orthopedic surgeon were studied. All the patients were consecutively enrolled at the Center of Diagnosis and Treatment for Joint Diseases, Drum Tower Hospital affiliated to the Medical School of Nanjing University from 2010 to 2012. All the subjects received venography 3–5 days after operation. We measured P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set. Results. No significant association was detected between P-selectin and DVT (all P values > 0.05). ΔsP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease ( P values were 0.03, 0.03, 0.04, and 0.02, resp.). Conclusion. P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty.
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DOI：
10.1073/pnas.91.19.8767
发表时间：
1994-09-13
影响因子：
11.1
作者：
CELI, A;PELLEGRINI, G;FURIE, B
通讯作者：
FURIE, B
影响因子：
4.3
作者：
Myers, DD;Hawley, AE;Wakefield, TW
通讯作者：
Wakefield, TW
深静脉血栓形成的生物标志物
影响因子：
4
作者：
Hou, Huacheng;Ge, Zhijuan;Jiang, Qing
通讯作者：
Jiang, Qing
DOI：
10.1302/0301-620x.79b5.7627
发表时间：
1997-09-01
影响因子：
--
作者：
Clarke, MT;Green, JS;Gregg, PJ
通讯作者：
Gregg, PJ
影响因子：
2.2
作者：
Myers, D;Farris, D;Wakefield, T
通讯作者：
Wakefield, T