Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses.
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses.
复制标题
针对新兴和重新出现病毒生命周期的各个阶段的小分子病毒抑制剂的发展。
DOI：
10.1007/s11684-017-0589-5
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发表时间：
2017-12
影响因子：
8.1
通讯作者：
Jiang S
中科院分区：
文献类型：
--
作者：
Wang X;Zou P;Wu F;Lu L;Jiang S
In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus. These viruses can interfere with the specific steps of viral life cycle by blocking the binding between virus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viral RNA replication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging viruses. We also discuss some general strategies for developing small-molecule viral inhibitors.
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影响因子：
14.9
作者：
Cao X;Li Y;Jin X;Li Y;Guo F;Jin T
通讯作者：
Jin T
影响因子：
4
作者：
Chu, Ling-Hon Matthew;Chan, Siu-Hong;Ngai, Sai-Ming
通讯作者：
Ngai, Sai-Ming
DOI：
10.1038/nrmicro2090
发表时间：
2009-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/s0140-6736(10)60357-1
发表时间：
2010-05-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Geisbert TW;Lee AC;Robbins M;Geisbert JB;Honko AN;Sood V;Johnson JC;de Jong S;Tavakoli I;Judge A;Hensley LE;Maclachlan I
通讯作者：
Maclachlan I
影响因子：
11.1
作者：
Cui L;Zou P;Chen E;Yao H;Zheng H;Wang Q;Zhu JN;Jiang S;Lu L;Zhang J
通讯作者：
Zhang J