Engineering complex orthopaedic tissues via strategic biomimicry.
Engineering complex orthopaedic tissues via strategic biomimicry.
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DOI：
10.1007/s10439-014-1190-6
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发表时间：
2015-03
影响因子：
3.8
通讯作者：
Lu HH
中科院分区：
文献类型：
--
作者：
Qu D;Mosher CZ;Boushell MK;Lu HH
当前再生工程的主要挑战在于同时形成多种类型的组织，以及将它们功能性地组装成复杂的组织或器官系统。组织与组织的同步性在肌肉骨骼系统中尤其重要，整体器官功能是通过骨与韧带、肌腱或软骨等软组织以及肌肉与肌腱的无缝整合来实现的。因此，人们正在积极研究用于功能性结缔组织单元（例如骨-韧带-骨）再生的复合组织支架设计，以代替传统的单组织系统（例如骨、韧带）。密切相关的是重建组织-组织界面的努力，这对于连接这些组织构件和促进宿主整合至关重要。该领域前沿的许多研究都集中在受生物启发的分层或梯度支架设计上，旨在重现不同组织区域固有的结构和成分不均匀性。因此，考虑到这些肌肉骨骼组织单元的复杂性，关键问题是如何确定最相关的参数来概括支架设计中的天然结构功能关系。因此，除了介绍复杂支架设计的最新技术之外，本次综述的重点是探索如何将战略仿生学应用于工程组织连接性。战略仿生学的目标是通过确定需要从自然中学习的内容并定义必须在支架设计中重现的基本基质特征来避免过度工程。本综述将讨论这种工程策略在最常见的肌肉骨骼组织单位（例如骨-韧带-骨、肌肉-肌腱-骨、软骨-骨）再生中的应用。预计这些令人兴奋的努力将实现软组织损伤的综合和功能修复，此外，为复合组织系统的发展以及最终的全肢体或关节再生奠定基础。
The primary current challenge in regenerative engineering resides in the simultaneous formation of more than one type of tissue, as well as their functional assembly into complex tissues or organ systems. Tissue-tissue synchrony is especially important in the musculoskeletal system, whereby overall organ function is enabled by the seamless integration of bone with soft tissues such as ligament, tendon, or cartilage, as well as the integration of muscle with tendon. Therefore, in lieu of a traditional single-tissue system (e.g. bone, ligament), composite tissue scaffold designs for the regeneration of functional connective tissue units (e.g. bone-ligament-bone) are being actively investigated. Closely related is the effort to re-establish tissue-tissue interfaces, which is essential for joining these tissue building blocks and facilitating host integration. Much of the research at the forefront of the field has centered on bioinspired stratified or gradient scaffold designs which aim to recapitulate the structural and compositional inhomogeneity inherent across distinct tissue regions. As such, given the complexity of these musculoskeletal tissue units, the key question is how to identify the most relevant parameters for recapitulating the native structure-function relationships in the scaffold design. Therefore, the focus of this review, in addition to presenting the state-of-the-art in complex scaffold design, is to explore how strategic biomimicry can be applied in engineering tissue connectivity. The objective of strategic biomimicry is to avoid over-engineering by establishing what needs to be learned from nature and defining the essential matrix characteristics that must be reproduced in scaffold design. Application of this engineering strategy for the regeneration of the most common musculoskeletal tissue units (e.g. bone-ligament-bone, muscle-tendon-bone, cartilage-bone) will be discussed in this review. It is anticipated that these exciting efforts will enable integrative and functional repair of soft tissue injuries, and moreover, lay the foundation for the development of composite tissue systems and ultimately, total limb or joint regeneration.
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影响因子：
7
作者：
Chiang, H.;Liao, C. -J.;Jiang, C. -C.
通讯作者：
Jiang, C. -C.
DOI：
10.1302/0301-620x.65b1.6337169
发表时间：
1983-01-01
影响因子：
--
作者：
BULLOUGH, PG;JAGANNATH, A
通讯作者：
JAGANNATH, A
影响因子：
2.4
作者：
Benjamin, M;Toumi, H;Milz, S
通讯作者：
Milz, S
羟基磷灰石在明胶接枝电纺聚（DL-丙交酯）纤维上的原位生长动力学
影响因子：
3.8
作者：
Cui, Wenguo;Li, Xiaohong;Weng, Jie
通讯作者：
Weng, Jie
影响因子：
38.3
作者：
通讯作者：
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