Nanotechnological strategies for engineering complex tissues.

Nanotechnological strategies for engineering complex tissues.
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DOI:
10.1038/nnano.2010.246
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发表时间:
2011-01
影响因子:
38.3
通讯作者:
--
中科院分区:
材料科学1区
文献类型:
--
作者:

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组织工程学的目标是开发受损组织和器官的功能替代品。在移植之前,细胞通常种植在生物材料支架上,这些支架重塑细胞外基质,为细胞提供对组织发育重要的信息。在这里,我们回顾了细胞外基质的纳米复合材料的性质,描述了不同组织的设计考虑因素,并讨论了纳米结构对支架性能的影响以及它们在监测工程组织行为方面的应用。我们还研究了用于触发特定组织发育过程的不同纳米设备,并就纳米技术在组织工程中应用的主要挑战和前景提出了我们的观点。
Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.
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