Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
复制标题
DOI：
10.1038/s41593-018-0265-3
复制
发表时间：
2018-12
影响因子：
25
通讯作者：
Kosik KS
中科院分区：
文献类型：
--
作者：
Nowakowski TJ;Rani N;Golkaram M;Zhou HR;Alvarado B;Huch K;West JA;Leyrat A;Pollen AA;Kriegstein AR;Petzold LR;Kosik KS
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, miRNAs operate non-uniformly upon the transcriptional profile with an as yet unknown logic. Shortcomings in defining miRNA-mRNA networks are limited knowledge of in vivo miRNA targets, and their abundance in single cells. By combining multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling, and innovative computational analyses using bipartite and co-expression networks, we show that miRNA-mRNA interactions operate as functional modules that often correspond to cell-type identities and undergo dynamic transitions during brain development. These networks are highly dynamic during development and over the course of evolution. One such interaction is between radial glia-enriched ORC4 and miR-2115, a great ape specific miRNA, which appears to control radial glia proliferation rates during human brain development.
登录
查看更多内容
影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T
影响因子：
4.5
作者：
Boumil, Rebecca M.;Letts, Verity A.;Frankel, Wayne N.
通讯作者：
Frankel, Wayne N.
影响因子：
16.2
作者：
Hevner, RF;Shi, LM;Rubenstein, JLR
通讯作者：
Rubenstein, JLR
影响因子：
16.2
作者：
Arcila ML;Betizeau M;Cambronne XA;Guzman E;Doerflinger N;Bouhallier F;Zhou H;Wu B;Rani N;Bassett DS;Borello U;Huissoud C;Goodman RH;Dehay C;Kosik KS
通讯作者：
Kosik KS
影响因子：
30.8
作者：
Guernsey, Duane L.;Matsuoka, Makoto;Samuels, Mark E.
通讯作者：
Samuels, Mark E.