Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach.
Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach.
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重新安排淀粉样蛋白β和Tau病理学之间的难题：一种以应用程序为中心的方法。
DOI：
10.3390/ijms25010259
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发表时间：
2023-12-23
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
After several years of research in the field of Alzheimer’s disease (AD), it is still unclear how amyloid-beta (Aβ) and Tau, two key hallmarks of the disease, mediate the neuropathogenic events that lead to AD. Current data challenge the “Amyloid Cascade Hypothesis” that has prevailed in the field of AD, stating that Aβ precedes and triggers Tau pathology that will eventually become the toxic entity in the progression of the disease. This perspective also led the field of therapeutic approaches towards the development of strategies that target Aβ or Tau. In the present review, we discuss recent literature regarding the neurotoxic role of both Aβ and Tau in AD, as well as their physiological function in the healthy brain. Consequently, we present studies suggesting that Aβ and Tau act independently of each other in mediating neurotoxicity in AD, thereafter, re-evaluating the “Amyloid Cascade Hypothesis” that places Tau pathology downstream of Aβ. More recent studies have confirmed that both Aβ and Tau could propagate the disease and induce synaptic and memory impairments via the amyloid precursor protein (APP). This finding is not only interesting from a mechanistic point of view since it provides better insights into the AD pathogenesis but also from a therapeutic point of view since it renders APP a common downstream effector for both Aβ and Tau. Subsequently, therapeutic strategies that act on APP might provide a more viable and physiologically relevant approach for targeting AD.
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影响因子：
3.5
作者：
Altafaj, X;Dierssen, M;Estivill, X
通讯作者：
Estivill, X
淀粉样蛋白β动力学与受伤的人脑中的神经系统状况相关。
影响因子：
56.9
作者：
Brody, David L.;Magnoni, Sandra;Schwetye, Kate E.;Spinner, Michael L.;Esparza, Thomas J.;Stocchetti, Nino;Zipfel, Gregory J.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
6
作者：
Avgerinos KI;Kalaitzidis G;Malli A;Kalaitzoglou D;Myserlis PG;Lioutas VA
通讯作者：
Lioutas VA
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
56.9
作者：
Cao, XW;Südhof, TC
通讯作者：
Südhof, TC