Detection and characterization of an H4N6 avian-lineage influenza A virus in pigs in the Midwestern United States.
Detection and characterization of an H4N6 avian-lineage influenza A virus in pigs in the Midwestern United States.
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DOI：
10.1016/j.virol.2017.08.021
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发表时间：
2017-11
期刊：
影响因子：
3.7
通讯作者：
Vincent AL
中科院分区：
文献类型：
--
作者：
Abente EJ;Gauger PC;Walia RR;Rajao DS;Zhang J;Harmon KM;Killian ML;Vincent AL
H4Nx病毒在加拿大和中国的猪中有报道，但在美国尚未在猪中发现。2015年底，在美国对猪群临床呼吸道疾病进行常规诊断调查期间，从猪中分离出一种禽源性H4N6甲型流感病毒。对养殖场其他猪和养猪生产系统内其他猪的血清学分析表明，该病毒不能有效地在猪与猪之间传播，无法确定猪的传播方式。在分子水平上对该分离物进行了鉴定，并对其在猪群中的发病机制和传播进行了实验研究。尽管病毒在猪的肺部复制并引起轻度肺部病变，但没有证据表明病毒在上呼吸道复制或传播给间接接触者，这支持了该农场的研究结果。
H4Nx viruses were reported in swine in Canada and China, but had not been recognized in swine in the USA. In late 2015, an avian-origin H4N6 influenza A virus was isolated from pigs in the United States during a routine diagnostic investigation of clinical respiratory disease in the herd. Serological analysis from additional pigs at the farm and other pigs within the swine production system indicated that the virus did not efficiently transmit from pig to pig and the mode of transmission to swine could not be determined. The isolate was characterized at the molecular level and the pathogenesis and transmission was experimentally evaluated in pigs. Although the virus replicated in the lungs of pigs and caused mild pulmonary lesions, there was no evidence of replication in the upper respiratory tract or transmission to indirect contacts, supporting the findings on the farm.
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