Abnormal expression of e-cadherin in gastric adenocarcinoma, and its correlation with tumor histopathology and helicobacter pylori infection.
Abnormal expression of e-cadherin in gastric adenocarcinoma, and its correlation with tumor histopathology and helicobacter pylori infection.
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DOI：
10.5812/ircmj.4032
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发表时间：
2013-03
影响因子：
0.4
通讯作者：
Jaam H
中科院分区：
文献类型：
--
作者：
Anbiaee R;Mojir Sheibani K;Torbati P;Jaam H
胃癌是世界上主要的癌症之一，尤其是在伊朗。胃癌的发生有许多基因组和分子因素，也有许多与肿瘤侵袭性相关的标志物。E-cadherin是一种肿瘤抑制基因，可产生E-cadherin跨膜蛋白，在上皮细胞的粘附和分化中起重要作用。在本研究中，我们评估了E-cadherin在伊朗胃腺癌患者中的异常表达率，并试图发现其与幽门螺杆菌感染和肿瘤组织病理学的相关性。对95例全部或部分胃切除术并胃腺癌患者的组织样本进行了历史队列调查。免疫组化和吉姆萨染色分别检测E-cadherin表达和幽门螺杆菌感染。评估E-cadherin异常表达与肿瘤浸润深度、肿瘤分化程度、肿瘤表型、肿瘤类型、肿瘤大小、肿瘤神经血管浸润、局部淋巴结累及幽门螺杆菌感染及患者年龄、性别等肿瘤组织病理学特征的关系。38%的患者E-cadherin表达异常，59%的患者感染h -幽门螺杆菌。E-cadherin异常表达与肿瘤分级及局部淋巴结受累有显著相关性。我们未发现E-cadherin异常表达与幽门螺杆菌感染、患者年龄和性别、肿瘤表型、肿瘤类型、肿瘤浸润深度、肿瘤大小、肿瘤神经血管浸润等因素有显著相关性。E-cadherin表达异常是胃腺癌的常见现象。研究显示，E-cadherin异常表达与肿瘤分级及局部淋巴结受累有显著相关性；因此，E-cadherin异常表达可作为胃腺癌肿瘤侵袭性的预测因素。
Gastric cancer is one of the leading cancers in the world especially in Iran. There are many genomic and molecular factors that cause gastric cancer to occur, and also there are many markers that associate with tumor invasiveness. E-cadherin is a tumor suppressor gene which produces E-cadherin transmembrane protein, a molecule which plays an important role in adhesion and differentiation of epithelial cells. In this study, we evaluated the prevalence of abnormal E-cadherin expression in Iranian patients with gastric adenocarcinoma, and tried to find its correlation with H. pylori infection and tumor histopathology. A historical cohort survey was performed on tissue samples obtained from 95 total or partial gastrectomy with gastric adenocarcinoma. The immunohistochemistry and Giemsa staining were used to assess E-cadherin expression, and H- pylori infection respectively. The association between abnormal E-cadherin expression and tumor histopathology characteristics include depth of tumor invasion, tumor differentiation, tumor phenotype, tumor type, tumor size, neurovascular invasion of tumor, and regional lymph node involvement and H- pylori infection and patient's age and sex, were evaluated in all patients. Abnormal E-cadherin expression was noted in 38% of patients, and 59% of patients were infected with H-pylori. A significant correlation was seen between abnormal E-cadherin expression, and tumor grade and regional lymph node involvement. We could not find any significant association between abnormal E-cadherin expression and H- pylori infection, patient's age and sex, tumor phenotype, tumor type, depth of tumor invasion, tumor size, and neurovascular invasion of tumor. Abnormal E-cadherin expression is a common phenomenon in gastric adenocarcinoma. The study showed a significant correlation between abnormal E-cadherin expression and tumor grade and regional lymph node involvement; so, abnormal E-cadherin expression may be used as a predictive factor for tumor invasiveness in gastric adenocarcinoma.
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