Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems
Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems
复制标题
大鼠内侧和外侧疼痛系统中伤害性刺激强度的整体编码
DOI：
10.1186/1744-8069-7-64
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发表时间：
2011-01
期刊：
影响因子：
3.3
通讯作者：
Luo, Fei
中科院分区：
文献类型：
--
作者：
Zhang, Yang;Wang, Ning;Wang, Jin-Yan;Chang, Jing-Yu;Woodward, Donald J.;Luo, Fei
背景对伤害性刺激强度的编码能力是痛觉神经加工的基础。人们普遍认为，强度信息是在感觉和情感途径中传递的。然而，目前还不清楚的编码模式是在丘脑皮层的大脑区域，以及是否双重疼痛系统共享类似的责任强度coding.ResultsMultichannelsingleunit记录被用来调查的活动，个别神经元和神经元合奏在大鼠大脑中的应用后，有害的激光刺激的强度增加到后爪。四个大脑区域进行了监测，包括两个在外侧感觉疼痛通路，即腹后外侧丘脑核和初级体感皮层，和两个在内侧通路，即内侧背侧丘脑核和前扣带皮层。在这项研究中，神经元数量，放电率，和合奏尖峰计数编码进行了检查。我们的结果表明，伤害性激光刺激诱发的双峰反应在所有记录的脑区。激光强度与反应神经元的数量、放电率以及质量峰计数（MSC）之间存在显著相关性。MSC编码通常比其他两种方法更有效。此外，在这两个途径的神经元的编码能力是compared.ConclusionThis研究证明了集体的贡献，内侧和外侧通路的神经元的伤害性强度编码。此外，我们提供的证据表明，整体尖峰计数可能是最可靠的方法编码疼痛强度的大脑。
BackgroundThe ability to encode noxious stimulus intensity is essential for the neural processing of pain perception. It is well accepted that the intensity information is transmitted within both sensory and affective pathways. However, it remains unclear what the encoding patterns are in the thalamocortical brain regions, and whether the dual pain systems share similar responsibility in intensity coding.ResultsMultichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral sensory pain pathway, namely, the ventral posterior lateral thalamic nuclei and the primary somatosensory cortex, and two in the medial pathway, namely, the medial dorsal thalamic nuclei and the anterior cingulate cortex. Neuron number, firing rate, and ensemble spike count codings were examined in this study. Our results showed that the noxious laser stimulation evoked double-peak responses in all recorded brain regions. Significant correlations were found between the laser intensity and the number of responsive neurons, the firing rates, as well as the mass spike counts (MSCs). MSC coding was generally more efficient than the other two methods. Moreover, the coding capacities of neurons in the two pathways were comparable.ConclusionThis study demonstrated the collective contribution of medial and lateral pathway neurons to the noxious intensity coding. Additionally, we provide evidence that ensemble spike count may be the most reliable method for coding pain intensity in the brain.
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影响因子：
56.9
作者：
TALBOT, JD;MARRETT, S;DUNCAN, GH
通讯作者：
DUNCAN, GH
影响因子：
7.4
作者：
Chen LM;Friedman RM;Roe AW
通讯作者：
Roe AW
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ
影响因子：
3.6
作者：
Jensen, Tanja;Granmo, Marcus;Schouenborg, Jens
通讯作者：
Schouenborg, Jens
DOI：
10.1523/jneurosci.2336-10.2010
发表时间：
2010-10-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Price NS;Born RT
通讯作者：
Born RT