Contribution of systemic and airway immune responses to pediatric obesity-related asthma.
Contribution of systemic and airway immune responses to pediatric obesity-related asthma.
复制标题
全身和气道免疫反应对儿童肥胖相关哮喘的影响。
DOI：
10.1016/j.prrv.2020.02.005
复制
发表时间：
2021-03
影响因子：
5.8
通讯作者：
Rastogi D
中科院分区：
文献类型：
--
作者：
Chen L;Collado K;Rastogi D
儿童肥胖会导致许多疾病，包括哮喘。虽然肥胖引起哮喘的确切机制尚不清楚，但有文献表明肥胖哮喘儿童的先天性和适应性全身和气道免疫反应与正常体重哮喘儿童不同。在儿童肥胖相关性哮喘中，有非过敏性或非T2表型的全身性辅助性T细胞（Th）1极化和过敏性Th细胞反应的报道。有初步证据表明，遗传和表观遗传机制有助于这些免疫反应。对非T2免疫应答的生物学的初步研究已经鉴定了CDC 42途径中基因的上调。CDC42是一种RhoGT4，在Th细胞生理学中起关键作用，包括优先幼稚Th细胞分化为Th1细胞，以及细胞因子产生和胞吐作用。这些新的途径是有希望的发现，以指导肥胖相关哮喘的靶向治疗开发，以解决疾病负担。
Childhood obesity contributes to many diseases, including asthma. Although the precise mechanism by which obesity causes asthma is not known, there is literature to suggest that innate and adaptive systemic and airway immune responses in obese children with asthma differ from those in normal-weight children with asthma. Both non-allergic or non-T2 phenotype with systemic T helper (Th)1 polarization and allergic Th cell responses have been reported in childhood obesity-related asthma. There is preliminary evidence to suggest that genetic and epigenetic mechanisms contribute to these immune responses. Initial investigations into the biology of non-T2 immune responses have identified upregulation of genes in the CDC42 pathway. CDC42 is a RhoGTPase that plays a key role in Th cell physiology, including preferential naïve Th cell differentiation to Th1 cells, as well as cytokine production and exocytosis. These novel pathways are promising findings to direct targeted therapy development for obesity-related asthma to address the disease burden.
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DOI：
10.1016/j.jaci.2011.03.036
发表时间：
2011-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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影响因子：
2.4
作者：
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影响因子：
4.4
作者：
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通讯作者：
Hivroz, Claire
DOI：
10.4049/jimmunol.1601520
发表时间：
2017-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Elliott MR;Koster KM;Murphy PS
通讯作者：
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影响因子：
14.2
作者：
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通讯作者：
Sutherland, E. Rand