Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences.
Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences.
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DOI：
10.3389/fimmu.2017.01633
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发表时间：
2017
影响因子：
7.3
通讯作者：
Blumenthal A
中科院分区：
文献类型：
--
作者：
Donovan ML;Schultz TE;Duke TJ;Blumenthal A
结核病（TB）仍然是全球主要的健康威胁。防治结核病的迫切需要包括针对药物敏感和耐药性结核病的改进和创新的治疗方案，以及区分活动性和潜伏性疾病并能够监测治疗成功或失败的可靠生物指标。结核病患者和结核分枝杆菌感染动物模型中显著的干扰素（IFN）诱导基因标签引起了人们对I型IFN在宿主对分枝杆菌感染应答中的作用的极大关注。在这里，我们回顾了最近的发展，在理解的先天免疫途径，驱动I型干扰素反应在分枝杆菌感染的宿主细胞和功能性后果的主机防御结核分枝杆菌，这样的见解可能会被利用为有针对性的主机导向的免疫治疗和可靠的生物标志物的发展。
Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB include improved and innovative treatment options for drug-sensitive and -resistant TB as well as reliable biological indicators that discriminate active from latent disease and enable monitoring of treatment success or failure. Prominent interferon (IFN) inducible gene signatures in TB patients and animal models of Mycobacterium tuberculosis infection have drawn significant attention to the roles of type I IFNs in the host response to mycobacterial infections. Here, we review recent developments in the understanding of the innate immune pathways that drive type I IFN responses in mycobacteria-infected host cells and the functional consequences for the host defense against M. tuberculosis, with a view that such insights might be exploited for the development of targeted host-directed immunotherapies and development of reliable biomarkers.
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影响因子：
8.7
作者：
Cliff JM;Kaufmann SH;McShane H;van Helden P;O'Garra A
通讯作者：
O'Garra A
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1126/science.1224026
发表时间：
2012-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bogunovic D;Byun M;Durfee LA;Abhyankar A;Sanal O;Mansouri D;Salem S;Radovanovic I;Grant AV;Adimi P;Mansouri N;Okada S;Bryant VL;Kong XF;Kreins A;Velez MM;Boisson B;Khalilzadeh S;Ozcelik U;Darazam IA;Schoggins JW;Rice CM;Al-Muhsen S;Behr M;Vogt G;Puel A;Bustamante J;Gros P;Huibregtse JM;Abel L;Boisson-Dupuis S;Casanova JL
通讯作者：
Casanova JL
影响因子：
15.9
作者：
Antonelli, Lis R. V.;Rothfuchs, Antonio Gigliotti;Sher, Alan
通讯作者：
Sher, Alan
影响因子：
3.7
作者：
Blankley S;Graham CM;Turner J;Berry MP;Bloom CI;Xu Z;Pascual V;Banchereau J;Chaussabel D;Breen R;Santis G;Blankenship DM;Lipman M;O'Garra A
通讯作者：
O'Garra A