Delivering regenerative cues to the heart: cardiac drug delivery by microspheres and peptide nanofibers.
Delivering regenerative cues to the heart: cardiac drug delivery by microspheres and peptide nanofibers.
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DOI：
10.1007/s12265-010-9210-x
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发表时间：
2010-10
影响因子：
3.4
通讯作者：
Davis, Michael E.
中科院分区：
文献类型：
--
作者：
Sy, Jay C.;Davis, Michael E.
关键词：
我们对心脏再生至关重要的信号通路和线索的理解正在被世界各地的实验室改进。随着使心脏再生的各种机制逐渐被阐明，也必须开发适合这些潜在治疗的运载工具。本文综述了两种技术的研究进展，一种是用于控释系统的新型可降解微球，另一种是用于细胞和因子传递的自组装肽纳米纤维。聚酮是一类新的可吸收聚合物，由于其生物相容性降解产物，非常适合治疗炎症性疾病。聚酮已被用于给心肌梗死大鼠模型提供小分子抑制剂和抗氧化蛋白，并显著改善心功能。自组装肽纳米纤维是一类水凝胶，它是由99%的水组成的明确的支架，可以加入各种生物活性线索。我们的实验室和其他实验室所做的工作已经证明，使用这些水凝胶作为蛋白质的药物递送载体以及移植细胞的特定微环境，功能得到了改善。将用于药物缓释的非炎症性聚合物微球与自组装纳米纤维相结合，产生多功能支架，可能很快推动心肌梗死后身体的愈合反应走向心脏再生。
Our understanding of signaling pathways and cues vital for cardiac regeneration is being refined by laboratories worldwide. As various mechanisms enabling cardiac regeneration are becoming elucidated, delivery vehicles suited for these potential therapeutics must also be developed. This review focuses on advances in two technologies, novel degradable microspheres for controlled release systems and self-assembling peptide nanofibers for cell and factor delivery. Polyketals, a new class of resorbable polymers, are well suited for treating inflammatory diseases due to biocompatible degradation products. Polyketals have been used to deliver small molecule inhibitors and antioxidant proteins to rat models of myocardial infarction with notable improvements in cardiac function. Self-assembling peptide nanofibers are a class of hydrogels that are well-defined scaffolds made up of 99% water and amenable to incorporation of a variety of bioactive cues. Work done by our laboratory and others have demonstrated functional improvements using these hydrogels as both a drug delivery vehicle for proteins as well as a defined microenvironment for transplanted cells. Combining non-inflammatory polymer microspheres for sustained release of drugs with self-assembling nanofibers yields multifunctional scaffolds that may soon drive the body’s healing response following myocardial infarction towards cardiac regeneration.
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影响因子：
13.8
作者：
Godin B;Sakamoto JH;Serda RE;Grattoni A;Bouamrani A;Ferrari M
通讯作者：
Ferrari M
DOI：
10.1016/s0021-9673(00)93969-4
发表时间：
1987-12-18
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
HOCHULI, E;DOBELI, H;SCHACHER, A
通讯作者：
SCHACHER, A
影响因子：
7.8
作者：
George, Jon C.
通讯作者：
George, Jon C.
影响因子：
18.2
作者：
Jin, Jiyong;Jeong, Sung In;Kim, Kyung-Soo
通讯作者：
Kim, Kyung-Soo
影响因子：
4.3
作者：
Khaper, N;Kaur, K;Singal, PK
通讯作者：
Singal, PK