Manipulating critical period closure across different sectors of the primary auditory cortex.
Manipulating critical period closure across different sectors of the primary auditory cortex.
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DOI：
10.1038/nn.2144
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发表时间：
2008-08
影响因子：
25
通讯作者：
Merzenich, Michael M.
中科院分区：
文献类型：
--
作者：
de Villers-Sidani, Etienne;Simpson, Kimberly L.;Lu, Y-F;Lin, Rick C. S.;Merzenich, Michael M.
在早期大脑发育过程中，通过“成人”经验依赖的可塑性，神经回路被塑造成高保真地代表外部世界。当在安静的环境中长大时，大鼠初级听觉皮层（A1）有一个明确的“关键时期”，持续数天，用于表征声音频率。环境噪声的加入延长了临界时间，这是噪声水平的变量函数。目前尚不清楚是否应该将关键期关闭视为适用于所有A1的统一的外部门控事件，或者是否由该皮质区域渐进式的、局部的、活动驱动的变化控制。我们发现，在有限的噪声波段中饲养大鼠，会导致代表无噪声波段的A1区临界期关闭，而在噪声暴露区，临界期似乎保持开放，那里的皮质在功能和生理上仍未成熟。
During early brain development and through ‘adult’ experience-dependent plasticity, neural circuits are shaped to represent the external world with high fidelity. When raised in a quiet environment, the rat primary auditory cortex (A1) has a well-defined ‘critical period’, lasting several days, for its representation of sound frequency. The addition of environmental noise extends the critical period duration as a variable function of noise level. It remains unclear whether critical period closure should be regarded as a unified, externally gated event that applies for all of A1 or if it is controlled by progressive, local, activity-driven changes in this cortical area. We found that rearing rats in the presence of a spectrally limited noise band resulted in the closure of the critical period for A1 sectors representing the noise-free spectral bands, whereas the critical period appeared to remain open in noise-exposed sectors, where the cortex was still functionally and physically immature.
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影响因子：
2.5
作者：
HENDRICKSON, AE;VANBREDERODE, JFM;CELIO, MR
通讯作者：
CELIO, MR
DOI：
10.1073/pnas.0508239102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Chang, EF;Bao, SW;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
56.9
作者：
Crair, MC;Gillespie, DC;Stryker, MP
通讯作者：
Stryker, MP
影响因子：
25
作者：
Daw, Michael I.;Ashby, Michael C.;Isaac, John T. R.
通讯作者：
Isaac, John T. R.
影响因子：
2.5
作者：
EGGERMONT, JJ
通讯作者：
EGGERMONT, JJ