Hyperinflation is associated with increased respiratory rate and is a more sensitive measure of cystic fibrosis lung disease during infancy compared to forced expiratory measures.
Hyperinflation is associated with increased respiratory rate and is a more sensitive measure of cystic fibrosis lung disease during infancy compared to forced expiratory measures.
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DOI：
10.1002/ppul.25538
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发表时间：
2021-09
影响因子：
3.1
通讯作者：
Ren CL
中科院分区：
文献类型：
--
作者：
Muston HN;Slaven JE;Tiller C;Clem C;Ferkol TW;Ranganathan S;Davis SD;Ren CL
本研究的目的是确定与通过新生儿筛查（NBS）诊断的囊性纤维化（CF）婴儿肺功能检查（iPFT）异常相关的临床特征，特别是功能性残气量（FRC）。我们假设前6-12个月的营养状况不良与12-24个月时FRC增加相关。本研究结合了从正在进行的研究中回顾性和前瞻性收集的数据以及针对临床适应症进行的iPFT。从电子病历中获取人口统计学和临床特征。用力呼气流量和容量采用快速胸腹容积技术（RVRTC）获得，FRC通过体积描记术测量。共有45名CF NBS婴儿在12-24个月之间进行了iPFT。平均用力肺活量、0.5秒用力呼气量和用力呼气流量均在正常范围内。相反，平均FRC z评分为2.18（95%CI=1.48，2.88），平均呼吸频率（RR）z评分为1.42（95%CI=0.95，1.89）。营养不良与肺功能异常之间无显著相关性。然而，较高的RR与FRC增加之间存在显著相关性，RR截止值为36次呼吸/min时，检测过度充气的灵敏度为92%，特异性为32%。这些结果表明，FRC是一个更敏感的早期CF肺疾病的测量比RVRTC测量和RR可能是一个简单的，非侵入性的临床指标，以确定CF NBS婴儿过度充气。
The goal of this study was to identify clinical features associated with abnormal infant pulmonary function tests (iPFTs), specifically functional residual capacity (FRC), in infants with cystic fibrosis (CF) diagnosed via newborn screen (NBS). We hypothesized that poor nutritional status in the first 6–12 months would be associated with increased FRC at 12–24 months. This study utilized a combination of retrospectively and prospectively collected data from ongoing research studies and iPFTs performed for clinical indications. Demographic and clinical features were obtained from the electronic medical record. Forced expiratory flows and volumes were obtained using the raised volume rapid thoracoabdominal technique (RVRTC) and FRC was measured via plethysmography. A total of 45 CF NBS infants had iPFTs performed between 12–24 months. Mean forced vital capacity, forced expiratory volume in 0.5 second, and forced expiratory flows were all within normal limits. In contrast, the mean FRC z-score was 2.18 (95%CI=1.48, 2.88) and the mean respiratory rate (RR) z-score was 1.42 (95%CI=0.95, 1.89). There was no significant association between poor nutritional status and abnormal lung function. However, there was a significant association between higher RR and increased FRC, and a RR cutoff of 36 breaths/min resulted in 92% sensitivity to detect hyperinflation with 32% specificity. These results suggest that FRC is a more sensitive measure of early CF lung disease than RVRTC measurements and that RR may be a simple, non-invasive clinical marker to identify CF NBS infants with hyperinflation.
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影响因子：
24.3
作者：
Ranganathan, SC;Goetz, I;Stocks, J
通讯作者：
Stocks, J
影响因子：
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影响因子：
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作者：
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通讯作者：
Stocks, Janet
影响因子：
3.1
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影响因子：
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作者：
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